8th edition AJCC-UICC staging of cancers of the esophagus and esophagogastric junction

The 8th edition AJCC-UICC staging of cancers of the esophagus and esophagogastric junction is the most up to date staging system for esophageal cancers.

For a more general article on oeaphageal cancer staging refer to - esophageal cancer (staging)

It follows a TNM system.

Staging
  • T staging
    • Tx: tumor cannot be assessed
    • T0: no evidence of primary tumor
    • Tis: high-grade dysplasia, defined as malignant cells confined by the basement membrane
    • T1: tumor invades the lamina propria, muscularis mucosae, or submucosa
      • T1a: invades the lamina propria or muscularis mucosae
      • T1b: tumor invades the submucosa
    • T2: invades the muscularis propria
    • T3: invades adventitia
    • T4: invades adjacent structures
      • T4a: invasion of pleura, pericardium, azygos vein, diaphragm, or peritoneum
      • T4b: invasion of other adjacent structures, such as aorta, vertebral body, or trachea
  • N staging
    • Nx: lymph nodes cannot be assessed
    • N0: no regional lymph node metastasis
    • N1: 1-2 regional lymph nodes
    • N2: 3-6 regional lymph nodes
    • N3: 7 or more regional lymph nodes
  • M staging
    • M0: no distant metastasis
    • M1: distant metastasis

Adenocarcinoma: G category (histological)

  • Gx: differentiation cannot be assessed
  • G1: well differentiated. > 95% of tumor is composed of well-formed glands
  • G2: moderately differentiated. 50% to 95% of tumor showing gland formation
  • G3: poorly differentiated; composed of nest and sheets of cells with <50% of tumor demonstrating glandular formation

Squamous cell carcinoma G category (histological)

  • Gx: differentiation cannot be assessed
  • G1: well-differentiated: prominent keratinization with pearl formation and a minor component of nonkeratinizing basal-like cells; tumor cells arranged in sheets, and low mitotic counts
  • G2: moderately differentiated; variable histologic features, ranging from parakeratotic to poorly keratinizing lesions; generally, pearl formation absent
  • G3: poorly differentiated; predominantly of basal-like cells forming large and small nests with frequent central necrosis; nests consist of sheets or pavement-like arrangements of tumor cells, and occasionally punctuated by small numbers of parakeratotic or keratinizing cells

Squamous cell carcinoma L category

  • Lx: location unknown
  • upper: cervical esophagus to lower border of azygos vein
  • middle: lower border of azygos vein to lower border of inferior pulmonary vein
  • lower: lower border of inferior pulmonary vein to stomach, including esophagogastric junction
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Article information

rID: 69164
Tag: refs
Synonyms or Alternate Spellings:
  • Oesophageal cancer staging 8th edition

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