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Citation:
Weerakkody Y, Yap J, Haouimi A, et al. Adenosquamous carcinoma of endometrium (historical). Reference article, Radiopaedia.org (Accessed on 29 Mar 2024) https://doi.org/10.53347/rID-18158
Adenosquamous carcinoma of the endometrium is term formerly used to describe a rare histological subtype of endometrial cancer that contains both malignant glandular and malignant squamous components.
As of the 5th edition (2020) of the WHO classification of tumors of the uterine corpus, the subtype is no longer present. Instead, it is incorporated into the histological description for endometrioid carcinoma of the endometrium as a villoglandular tumor that demonstrates squamous differentiation (which occurs in 10-25% of cases) 6.
It has previously been reported to occur in a slightly younger age group 4 with a slightly higher grade at presentation when compared to pure adenocarcinoma of the endometrium 2,5. However, the revised classification has moved away from the use of morphological features for prognostication, instead becoming increasingly reliant on molecular parameters such as POLE gene mutation status 6.
NB: adenosquamous carcinoma remains a histological subtype of cervical epithelial tumors.
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1. Haqqani MT, Fox H. Adenosquamous carcinoma of the endometrium. J. Clin. Pathol. 1976;29 (11): 959-66. J. Clin. Pathol. (link) - Free text at pubmed - Pubmed citation
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2. Pekin T, Yildizhan B, Eren F et-al. Adenocarcinoma, adenoacanthoma, and mixed adenosquamous carcinoma of the endometrium. Eur. J. Gynaecol. Oncol. 2001;22 (2): 151-3. - Pubmed citation
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3. Sala E, Wakely S, Senior E et-al. MRI of malignant neoplasms of the uterine corpus and cervix. AJR Am J Roentgenol. 2007;188 (6): 1577-87. doi:10.2214/AJR.06.1196 - Pubmed citation
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4. Acheson N, Luesley D. Gynaecological Oncology for the MRCOG and Beyond. (2010) ISBN:1906985219. Read it at Google Books - Find it at Amazon
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5. Demopoulos RI, Dubin N, Noumoff J et-al. Prognostic significance of squamous differentiation in stage I endometrial adenocarcinoma. Obstet Gynecol. 1986;68 (2): 245-50. - Pubmed citation
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6. W. H. O. Classification WHO Classification of Tumours Editorial Board, Who Classification of Tumours Editorial. Female Genital Tumours: Who Classification of Tumours. (2020) ISBN: 9789283245049 - Google Books
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