Adenosquamous carcinoma of endometrium (historical)

Last revised by Joshua Yap on 8 Aug 2022

Adenosquamous carcinoma of the endometrium is term formerly used to describe a rare histological subtype of endometrial cancer that contains both malignant glandular and malignant squamous components.

As of the 5th edition (2020) of the WHO classification of tumors of the uterine corpus, the subtype is no longer present. Instead, it is incorporated into the histological description for endometrioid carcinoma of the endometrium as a villoglandular tumor that demonstrates squamous differentiation (which occurs in 10-25% of cases) 6.

It has previously been reported to occur in a slightly younger age group 4 with a slightly higher grade at presentation when compared to pure adenocarcinoma of the endometrium 2,5. However, the revised classification has moved away from the use of morphological features for prognostication, instead becoming increasingly reliant on molecular parameters such as POLE gene mutation status 6.

NB: adenosquamous carcinoma remains a histological subtype of cervical epithelial tumors.

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