Adie syndrome, also known as Holmes-Adie syndrome, is a rare neurological disorder.
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Epidemiology
Adie syndrome is a rare condition that is most commonly seen in young females in their fourth decade of life 2,3.
Clinical presentation
Patients most commonly present with a classic triad of:
- diaphoresis
- absent deep tendon reflexes, e.g. ankle jerk
- an Adie pupil: tonically dilated and responds poorly or not at all to light
Unilateral pupillary symptoms are more common than bilateral 2,3. A few of the other symptoms are emotional fluctuations, headache and facial pain 4.
Pathology
It is thought to result from damage to the ciliary ganglion and the dorsal root ganglion by viral or bacterial infections, however, there are idiopathic etiologies 1,3.
History and etymology
It was named after the British-Australian neurologist William John Adie (1886 - 1935) 1.