The Amsterdam criteria, also known as the ICG–HNPCC criteria, were established for the selection of families with hereditary non-polyposis colorectal cancer (HNPCC) for research but are not exclusionary for the diagnosis of HNPCC 5.
Usage
Amsterdam criteria were first established in 1990 and revised in 1998. Both Amsterdam criteria I and II can be used in research depending on the study aim and allow comparison between data sets 5. Amsterdam criteria II in common use (c. 2022) along with the revised Bethesda guidelines 4.
Amsterdam criteria II has a high specificity (98%) but low sensitivity (~30%; range 22-42%) 4.
Classification
Amsterdam criteria I (classic ICG–HNPCC criteria)
There should be at least 3 relatives with colorectal cancer (CRC), and all the following criteria should be present 5:
1 should be a first-degree relative of the other 2
at least 2 successive generations should be affected
at least 1 CRC tumor should be diagnosed before the age of 50 years
familial adenomatous polyposis (FAP) should be excluded
tumors should be verified by pathological examination
Amsterdam criteria II (revised ICG–HNPCC criteria)
at least 3 relatives with HNPCC-associated cancer (CRC, cancer of the endometrium, small bowel, ureter, or renal pelvis)
1 should be a first-degree relative of the other 2
at least successive generations should be affected
at least 1 should be diagnosed before the age of 50 years
FAP should be excluded in any CRC cases
tumors should be verified by pathological examination
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