Revision 2 for 'Anaplastic lymphoma kinase (ALK) fusion oncogene positive non small cell lung cancer'

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Anaplastic lymphoma kinase (alk) fusion oncogene positive non small cell lung cancer

Anaplastic lymphoma kinase (ALK) fusion oncogene positive non small cell lung cancer refers to a specific set of  non small cell lung cancers that contain an inversion in chromosome 2.

They are associated with specific clinical features, including never or light smoking history, younger age, and adenocarcinoma with signet ring or acinar histology. 

Epidemiology

 It is found in approximately 5 percent of non small cell lung cancer.

Pathology

They resulting in the novel fusion oncogene EML4-ALK rearrangement is transforming both in vitro and in vivo and defines a distinct clinicopathologic subset of NSCLC.  ALK gene arrangements are largely mutually exclusive with epidermal growth factor receptor (EGFR) and KRAS mutations.

Treatment and prognosis

They are more responsive to anaplastic lymphoma kinase (ALK) and c-Met receptor kinases such as Crizotinib.

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