Revision 16 for 'Anterior mediastinal germ cell tumors'All Revisions
Anterior mediastinal germ cell tumors
- non-seminomatous germ cell tumors (NSGCT)
Alternatively, anterior mediastinal germ cell tumors can be thought of as benign and malignant 1:
- mature teratoma
- mature teratoma with an immature component of less than 50% 1
- all others
Mature teratomas are the most frequent histology encountered in the mediastinum (see mediastinal teratoma), and account for ~60% (range 50-70%) of all mediastinal germ cell tumors 2.
It is difficult to distinguish between the various malignant histologies, and clinical correlation with serum tumor markers (alpha-foetoprotein, beta-HCG) and biopsy are usually required.