Antral follicle count
Citation, DOI, disclosures and article data
At the time the article was created Avni K P Skandhan had no recorded disclosures.
View Avni K P Skandhan's current disclosuresAt the time the article was last revised Owen Kang had no recorded disclosures.
View Owen Kang's current disclosures- Basal antral follicle count
- AF count
Antral follicle count (AFC) or basal antral follicle count is a test performed to check a female individual's ovarian reserve.
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Principle
A female is born with a lifetime supply of eggs and as she enters puberty these eggs develop. During and after puberty these follicles develop and are released on a monthly basis.
An antral follicle is a resting follicle and appears as a small fluid-filled sac which contains an immature egg. These follicles can be measured and counted on cycle days 2, 3 and 5. The antral follicles vary every month.
Procedure
Antral follicle count is rightly done on day 3 of the cycle by a Trans vaginal ultrasound. Initially the ovarian volume of both the ovaries is calculated. Further the number of small antral follicles in both the ovaries is measured. These follicles could vary in size from 2-10 mm.
Analysis
What is considered a normal AFC varies between institutions. It is roughly considered to be about 3-8 per ovary. The AFC count is a major predictor of the ovarian reserve and could reflect the size of the remaining primordial follicle pool.
Low fertility is characterized by low numbers of oocytes and are usually associated with high follicle stimulating hormone (FSH) levels.
It is considered to be more accurate than the basal FSH testing for older women >44 years of age when predicting IVF outcome.
When an average to high number of antral follicles (eight or more) are visible on the ultrasound, fertility specialists expect to be able to retrieve an adequate number of eggs and the pregnancy rates are higher than average. If few antral follicles are evident, a poorer response is expected and the IVF cycle could be canceled to attempt better counts the following month.
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See also
References
- 1. Kwee J, Elting ME, Schats R et-al. Ovarian volume and antral follicle count for the prediction of low and hyper responders with in vitro fertilization. Reprod. Biol. Endocrinol. 2007;5 (1): 9. doi:10.1186/1477-7827-5-9 - Free text at pubmed - Pubmed citation
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Lujan ME, Chizen DR, Peppin AK et-al. Assessment of ultrasonographic features of polycystic ovaries is associated with modest levels of inter-observer agreement. J Ovarian Res.2 (1): 6. doi:10.1186/1757-2215-2-6 - Free text at pubmed - Pubmed citationCode Contextif (isset($aDataSource[2]) && isset($aDataSource[3])) {
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- 3. Adibi A, Mardanian F, Hajiahmadi S. Comparison of Ovarian volume and Antral follicle count with Endocrine tests for prediction of responsiveness in ovulation induction protocols. Adv Biomed Res. 2013;1: 71. Free text at pubmed - Pubmed citation
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