The original description of the Askin tumor (by Askin and Rosai in 1979 1), and many studies following it have led to a great deal of confusion. Until recently it has been considered a separate entity or as a type of peripheral primitive neuroectodermal tumor, usually of the chest wall.
However, recent genetic research has led to the conclusion that it is essentially the same as Ewing sarcoma, and now is part of the collective term Ewing sarcoma family of tumors, sharing similar demographics, imaging findings and prognosis 2,3. Please see Ewing sarcoma of the chest wall for more detail.
While histologically the tumors are similar to an Ewing sarcoma, their typical location and growth pattern make the tumor a distinct radiographic entity.
- 1. Askin FB, Rosai J, Sibley RK et-al. Malignant small cell tumor of the thoracopulmonary region in childhood: a distinctive clinicopathologic entity of uncertain histogenesis. Cancer. 1979;43 (6): 2438-51. [pubmed citation]
- 2. Tateishi U, Gladish GW, Kusumoto M et-al. Chest wall tumors: radiologic findings and pathologic correlation: part 2. Malignant tumors. Radiographics. 23 (6): 1491-508. doi:10.1148/rg.236015527 [pubmed citation]
- 3. Iwamoto Y. Diagnosis and treatment of Ewing's sarcoma. Jpn. J. Clin. Oncol. 2007;37 (2): 79-89. doi:10.1093/jjco/hyl142 [pubmed citation]