Bartter syndrome is a rare inherited renal disorder.
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Pathology
Bartter syndrome is characterized by hyperplasia of the juxtaglomerular cells along with:
- hypokalemia
- metabolic alkalosis
- hypotension/normotension
- elevated plasma renin
- elevated aldosterone
- antenatal polyhydramnios
Classification
There are two subtypes of Bartter syndrome:
- classic: presents in early childhood with polyuria, polydipsia with a predisposition to dehydration
- neonatal: presents earlier
History and etymology
First described in 1962 by American endocrinologist Frederic Crosby Bartter (1914-1983) 3.
See also
- Gitelman syndrome: a closely associated disorder, milder than both subtypes of Bartter syndrome
- Schwartz-Bartter syndrome: a separate entity characterized by hypertonicity of urine, hyponatremia and inability to excrete water load