Revision 35 for 'Behçet disease'

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Behçet disease

Behçet disease is a multisystemic and chronic inflammatory vasculitis of unknown etiology.


The mean age at which Behçet disease occurs is 20-30 years. The disease is most prevalent in the Mediterranean region, Middle East and East Asia. The highest incidence has been reported in Turkey. Males are affected 2-5 times more often than females.

Clinical presentation

The classic clinical triad of Behçet disease consists of:

  1. oral ulceration
  2. genital ulceration
  3. ocular manifestations

Additional clinical manifestations include skin, joints, gastrointestinal tract, genitourinary tract, central nervous system, cardiovascular system, and lung involvement. Vascular complications develop in ~30% (20-40%) of patients with Behçet disease.


The underlying pathologic process in Behçet disease is vasculitis, and perivascular inflammatory infiltrates affecting vessels of differing sizes in various organs.


Primarily involves four main systems:

Treatment and prognosis

The disease may recur, progress, or resolve (either spontaneously, within a few weeks to several months, or with corticosteroid therapy).

History and etymology

It is named after Hulusi Behçet (1889-1948), Turkish dermatologist.

Differential diagnosis

On imaging consider:

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