Birbeck granules
Last revised by Daniel J Bell on 18 Apr 2022
Citation, DOI, disclosures and article data
Citation:
Weerakkody Y, Bell D, Birbeck granules. Reference article, Radiopaedia.org (Accessed on 18 Apr 2024) https://doi.org/10.53347/rID-98473
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rID:
98473
Article created:
26 Mar 2022,
Yuranga Weerakkody ◉
Disclosures:
At the time the article was created Yuranga Weerakkody had no recorded disclosures.
View Yuranga Weerakkody's current disclosures
Last revised:
18 Apr 2022,
Daniel J Bell ◉
Disclosures:
At the time the article was last revised Daniel J Bell had no recorded disclosures.
View Daniel J Bell's current disclosures
Revisions:
2 times, by
2 contributors -
see full revision history and disclosures
Systems:
Sections:
Synonyms:
- Birbeck's granules
- Birbeck bodies
Birbeck granules refer to unusual rod-shaped structures specific to Langerhans cells. Their origin and function remain undetermined. Langerin is a crucial component within Birbeck granules.
History and etymology
Birbeck granules were first described by Michael S Birbeck in 1961 3.
Related pathology
References
- 1. Mc Dermott R, Ziylan U, Spehner D et al. Birbeck Granules Are Subdomains of Endosomal Recycling Compartment in Human Epidermal Langerhans Cells, Which Form Where Langerin Accumulates. Mol Biol Cell. 2002;13(1):317-35. doi:10.1091/mbc.01-06-0300 - Pubmed
- 2. Thépaut M, Valladeau J, Nurisso A et al. Structural Studies of Langerin and Birbeck Granule: A Macromolecular Organization Model. Biochemistry. 2009;48(12):2684-98. doi:10.1021/bi802151w - Pubmed
- 3. Birbeck M, Breathnach A, Everall J. An Electron Microscope Study of Basal Melanocytes and High-Level Clear Cells (Langerhans Cells) in Vitiligo**From the Chester Beatty Research Institute, Royal Cancer Hospital, London, S.W. 3, and the Departments of Anatomy, and Dermatology, St. Mary's Hospital Medical School (University of London) London, W. 2, England. J Invest Dermatol. 1961;37(1):51-64. doi:10.1038/jid.1961.80
- 4. Cells Containing Birbeck Granules (Langerhans Cell Granules) in the Human Thymus. J Electron Microsc (Tokyo). 1970;19(3):271-6. doi:10.1093/oxfordjournals.jmicro.a049713
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