Revision 4 for 'Breast implant associated - anaplastic large cell lymphoma'

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Breast Implant Associated - Anaplastic Large Cell Lymphoma (BIA-ALCL)

Breast Implant Associated - Anaplastic Large Cell Lymphoma (BIA-ALCL) is a rare from of T-cell lymphoma which has primarily been associated with textured breast implants.  

Clinical presentation

Patients typically present with development of a late onset seroma or less commonly after identification of a breast or axillary mass. Cases have been reported as early as 1 year after surgery and as late as 37 years post augmentation mammoplasty. The average time to clinical presentation is reported to be approximately 10 years post breast augmentation. 


The exact causative etiology has not been confirmed however it is widely postulated that chronic inflammation due to a subclinical infective pathology may be causing malignant transformation of T-cells which are anapaestic lymphoma kinase negative and CD30 positive. 

Radiographic features







Treatment and prognosis

Principles of management:

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Differential diagnosis

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