Citation, DOI, disclosures and article data
Citation:
Feger J, Awal S, Knipe H, et al. Calcium volume score. Reference article, Radiopaedia.org (Accessed on 24 Apr 2024) https://doi.org/10.53347/rID-77553
The calcium volume score is a measure to quantify and calculate coronary artery calcium 1-3.
Its calculation includes all voxels with a Hounsfield attenuation >130 and this is done by multiplying the volume of each voxel, determined by the area and the slice thickness with the number of voxels showing calcification 1-3.
The calcium volume score has proven to be the most robust and reproducible method but is more susceptible to partial volume effects and seems more prone to variability between examinations regarding the position of the plaque in the axial slice 2. Unlike the Agatston score, the calcium volume score does not take factor calcium density into the calculation and measures merely the volume of calcified pixels 3.
It seems to be a significant and independent predictor of incidental major adverse cardiovascular events (MACE) within two years in symptomatic individuals 4.
As per the American College of Cardiology Foundation/American Heart Association (ACCF/AHA), consensus paper increased amounts of coronary calcium is associated with an increased risk for major cardiovascular events (MACE) 5:
- CAC score of 1-112: low risk with a relative risk ratio of 1.9 (95 CI: 1.3-2.8)
- CAC score of 100-400: moderate risk with a relative risk ratio of 4.3 (95% CI:3.1-6.1)
- CAC score of 401-999: high risk with a relative risk ratio of 7.2 (95% CI:5.2-9.9)
- CAC score >1000: very high risk with a relative risk ratio of 10.8 (95% CI:4.2-27.7)
See also
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1. Neves P, Andrade J, Monção H. Coronary Artery Calcium Score: Current Status. Radiol Bras. 2017;50(3):182-9. doi:10.1590/0100-3984.2015.0235 - Pubmed
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2. McCollough C, Ulzheimer S, Halliburton S, Shanneik K, White R, Kalender W. Coronary Artery Calcium: A Multi-Institutional, Multimanufacturer International Standard for Quantification at Cardiac CT. Radiology. 2007;243(2):527-38. doi:10.1148/radiol.2432050808 - Pubmed
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3. Sandfort V & Bluemke D. CT Calcium Scoring. History, Current Status and Outlook. Diagnostic and Interventional Imaging. 2017;98(1):3-10. doi:10.1016/j.diii.2016.06.007 - Pubmed
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4. Lo-Kioeng-Shioe M, Vavere A, Arbab-Zadeh A et al. Coronary Calcium Characteristics as Predictors of Major Adverse Cardiac Events in Symptomatic Patients: Insights From the CORE 320 Multinational Study. J Am Heart Assoc. 2019;8(6):e007201. doi:10.1161/JAHA.117.007201 - Pubmed
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5. Greenland P, Bonow R, Brundage B et al. ACCF/AHA 2007 Clinical Expert Consensus Document on Coronary Artery Calcium Scoring By Computed Tomography in Global Cardiovascular Risk Assessment and in Evaluation of Patients With Chest Pain. Journal of the American College of Cardiology. 2007;49(3):378-402. doi:10.1016/j.jacc.2006.10.001 - Pubmed
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6. Wolk M, Bailey S, Doherty J et al. ACCF/AHA/ASE/ASNC/HFSA/HRS/SCAI/SCCT/SCMR/STS 2013 Multimodality Appropriate Use Criteria for the Detection and Risk Assessment of Stable Ischemic Heart Disease. Journal of the American College of Cardiology. 2014;63(4):380-406. doi:10.1016/j.jacc.2013.11.009 - Pubmed
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