Acute motor axonal neuropathy
Last revised by Daniel J Bell on 12 Nov 2021
Citation, DOI, disclosures and article data
Citation:
Jindani I, Bell D, Luong D, et al. Acute motor axonal neuropathy. Reference article, Radiopaedia.org (Accessed on 28 Mar 2024) https://doi.org/10.53347/rID-12316
Permalink:
rID:
12316
Article created:
10 Nov 2010,
Imran Jindani
Disclosures:
At the time the article was created Imran Jindani had no recorded disclosures.
View Imran Jindani's current disclosures
Last revised:
12 Nov 2021,
Daniel J Bell ◉
Disclosures:
At the time the article was last revised Daniel J Bell had no recorded disclosures.
View Daniel J Bell's current disclosures
Revisions:
5 times, by
5 contributors -
see full revision history and disclosures
Systems:
Sections:
Synonyms:
- Acute motor axonal neuropathy (AMAN)
- Chinese paralytic syndrome
Acute motor axonal neuropathy (AMAN) is characterized as progressive symmetrical flaccid paralysis with areflexia. It is a pure motor axonopathy and is a variant of Guillain-Barré syndrome.
Terminology
In 1991, a short-lived epidemic of Guillain-Barré syndrome (GBS) was seen in Northern China. This gave rise to the short-lived and historical synonym "Chinese paralytic syndrome" for what was felt to be a form of acute motor axonal neuropathy, a distinct subtype of GBS. However studies showed that 3:
- sensory symptoms and signs played a larger part than was originally reported; this conclusion was supported by electrophysiological studies showing demyelination of sensory, as well as motor, fibers
- the clinical presentation was typical Guillain-Barré syndrome, therefore a separate monicker, i.e. Chinese paralytic syndrome, was unnecessary and therefore inappropriate
There are no articles published after 1996 in the medical literature using this term.
References
- 1. Gordon N. Chinese paralytic syndrome or acute motor axonal neuropathy. Arch. Dis. Child. 1994;70 (1): 64-5. doi:10.1136/adc.70.1.64 - Free text at pubmed - Pubmed citation
- 2. Shen Y, Xia G. What causes Chinese paralytic syndrome? Lancet. 1994;344 (8928): 1026. Lancet (link) - Pubmed citation
- 3. Tang X & Zhang X. Guillain-Barré Syndrome or "New" Chinese Paralytic Syndrome in Northern China? Electroencephalogr Clin Neurophysiol. 1996;101(2):105-9. doi:10.1016/0924-980x(95)00236-e - Pubmed
Incoming Links
Related articles: White matter disorders
- white matter
- normal myelination
- terminology
-
white matter disorders
-
demyelination
- anti-MOG associated encephalomyelitis
- Guillain-Barré syndrome (GBS)
- chronic inflammatory demyelinating polyneuropathy (CIDP)
- transverse myelitis
- tumefactive demyelinating lesions
- acute disseminated encephalomyelitis (ADEM)
- acute hemorrhagic encephalomyelitis (AHEM)
- neuromyelitis optica (NMO) (Devic disease)
-
multiple sclerosis (MS)
-
McDonald diagnostic criteria for MS (current 2017 revision)
- previous 2016 MAGNIMS consensus
- signs
- variants
-
McDonald diagnostic criteria for MS (current 2017 revision)
- radiologically isolated syndrome (RIS)
- clinically isolated syndrome (CIS)
- astrocytopathies
- leukoaxonopathies
- early-onset neuronal degenerative disorders
- giant axonal neuropathy
- hypomyelination with atrophy of the basal ganglia and cerebellum (H-ABC)
- hypomyelination with congenital cataract
- leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation
- hypomyelination with brainstem and spinal cord involvement and leg spasticity
- pol III-related leukodystrophies
- leukovasculopathies
- CADASIL
- CARASIL
- cathepsin A-related arteriopathy with strokes and leukoencephalopathy (CARASAL)
- cerebral amyloid angiopathy
- COL4A1 brain small-vessel disease
- Fabry disease
- heterozygous HTRA1-related cerebral small vessel disease
- leukoencephalopathy with calcifications and cysts (Labrun syndrome)
- pontine autosomal dominant microangiopathy with leukoencephalopathy (PADMAL)
- retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations (RVCL-S)
- microgliopathies
- myelin disorders
- hypomyelination
- demyelination
- myelin vacuolisation
- other
- adult polyglucosan body disease
- adult-onset autosomal dominant leukodystrophy
- cerebrotendinous xanthomathosis
- cystic leukoencephalopathy without megalencephaly
- L-2-hydroxyglutaric aciduria
-
lysosomal storage diseases
- free sialic acid storage disorders (e.g. Salla disease)
- Niemann-Pick disease
- peroxisomal disorders
- Sjögren-Larsson syndrome
-
demyelination