Chromophobe renal cell carcinoma

Changed by Henry Knipe, 16 May 2022

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Chromophobe renal cell carcinoma is one of the less common subtypes of renal cell carcinoma (RCC).

Epidemiology

This is the least common major subtype of RCC, occurring 5% of the time ¹. Similar incidence in men and women. There is an association with Birt-Hogg-Dubé syndrome^ref.

Pathology

This type of RCC arises from intercalated cells of collecting ducts ^1,2. The designation "chromophobe" arises because the tumour cells are less translucent than clear cell renal cell carcinomas during staining for histology ¹. They have a similar origin to oncocytomas ³.

Radiographic features

Ultrasound

presents similarly to other renal cell masses, with an isoechoic/hypoechoic masslike contour abnormality and flow on colour Doppler imaging

CT

relatively homogeneous contrast enhancement

MRI

isointense to kidney / maybe T2 hypointense
relatively homogeneous contrast enhancement
necrosis not common

Differential diagnosis

other subtypes of renal cell carcinoma
- clear cell RCC
- papillary RCC
oncocytoma
- chromophobe RCC and oncocytoma share a similar pathologic origin and have similar imaging features
- the classic "spoke wheel pattern of enhancement in oncocytomas has been reported in chromophobe RCC ²

-<p><strong>Chromophobe renal cell carcinoma</strong> is one of the less common subtypes of <a href="/articles/renal-cell-carcinoma-1">renal cell carcinoma</a> (RCC).</p><h4>Epidemiology</h4><p>This is the least common major subtype of RCC, occurring 5% of the time <sup>1</sup>. Similar incidence in men and women. There is an association with <a title="Birt-Hogg-Dubé syndrome" href="/articles/birt-hogg-dube-syndrome-5">Birt-Hogg-Dubé syndrome</a>.</p><h4>Pathology</h4><p>This type of RCC arises from intercalated cells of collecting ducts <sup>1,2</sup>. The designation "chromophobe" arises because the tumour cells are less translucent than clear cell renal cell carcinomas during staining for histology <sup>1</sup>. They have a similar origin to <a href="/articles/renal-oncocytoma">oncocytomas</a> <sup>3</sup>.</p><h4>Radiographic features</h4><h5>Ultrasound</h5><ul><li>presents similarly to other renal cell masses, with an isoechoic/hypoechoic masslike contour abnormality and flow on colour Doppler imaging</li></ul><h5>CT</h5><ul><li>relatively homogeneous contrast enhancement</li></ul><h5>MRI</h5><ul>
+<p><strong>Chromophobe renal cell carcinoma</strong> is one of the less common subtypes of <a href="/articles/renal-cell-carcinoma-1">renal cell carcinoma</a> (RCC).</p><h4>Epidemiology</h4><p>This is the least common major subtype of RCC, occurring 5% of the time <sup>1</sup>. Similar incidence in men and women. There is an association with <a href="/articles/birt-hogg-dube-syndrome-5">Birt-Hogg-Dubé syndrome</a> <sup>ref</sup>.</p><h4>Pathology</h4><p>This type of RCC arises from intercalated cells of collecting ducts <sup>1,2</sup>. The designation "chromophobe" arises because the tumour cells are less translucent than clear cell renal cell carcinomas during staining for histology <sup>1</sup>. They have a similar origin to <a href="/articles/renal-oncocytoma">oncocytomas</a> <sup>3</sup>.</p><h4>Radiographic features</h4><h5>Ultrasound</h5><ul><li>presents similarly to other renal cell masses, with an isoechoic/hypoechoic masslike contour abnormality and flow on colour Doppler imaging</li></ul><h5>CT</h5><ul><li>relatively homogeneous contrast enhancement</li></ul><h5>MRI</h5><ul>

References changed:

1. Vinay Kumar, Abul K. Abbas, Jon C. Aster. Robbins Basic Pathology. (2017) ISBN: 9780323353175 - <a href="http://books.google.com/books?vid=ISBN9780323353175">Google Books</a>
2. Prasad S, Humphrey P, Catena J et al. Common and Uncommon Histologic Subtypes of Renal Cell Carcinoma: Imaging Spectrum with Pathologic Correlation. Radiographics. 2006;26(6):1795-806; discussion 1806. <a href="https://doi.org/10.1148/rg.266065010">doi:10.1148/rg.266065010</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/17102051">Pubmed</a>
3. Lopes Vendrami C, Parada Villavicencio C, DeJulio T et al. Differentiation of Solid Renal Tumors with Multiparametric MR Imaging. Radiographics. 2017;37(7):2026-42. <a href="https://doi.org/10.1148/rg.2017170039">doi:10.1148/rg.2017170039</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/29131770">Pubmed</a>
1. Vinay Kumar, Abul K. Abbas, Jon C. Aster. Robbins Basic Pathology. (2017) <a href="https://books.google.co.uk/books?vid=ISBN9780323353175">ISBN: 9780323353175</a><span class="ref_v4"></span>
2. Prasad SR, Humphrey PA, Catena JR, Narra VR, Srigley JR, Cortez AD, Dalrymple NC, Chintapalli KN. Common and uncommon histologic subtypes of renal cell carcinoma: imaging spectrum with pathologic correlation. (2006) Radiographics : a review publication of the Radiological Society of North America, Inc. 26 (6): 1795-806; discussion 1806-10. <a href="https://doi.org/10.1148/rg.266065010">doi:10.1148/rg.266065010</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/17102051">Pubmed</a> <span class="ref_v4"></span>
3. Camila Lopes Vendrami, Carolina Parada Villavicencio, Todd J. DeJulio, Argha Chatterjee, David D. Casalino, Jeanne M. Horowitz, Daniel T. Oberlin, Guang-Yu Yang, Paul Nikolaidis, Frank H. Miller. Differentiation of Solid Renal Tumors with Multiparametric MR Imaging. (2017) RadioGraphics. 37 (7): 2026-2042. <a href="https://doi.org/10.1148/rg.2017170039">doi:10.1148/rg.2017170039</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/29131770">Pubmed</a> <span class="ref_v4"></span>

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