Chromophobe renal cell carcinoma
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- updated 18 Aug 2022:
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Chromophobe renal cell carcinoma is one of the less common subtypes of renal cell carcinoma (RCC).
Epidemiology
This is the least common major subtype of RCC, occurring 5% of the time 1. Similar incidence in men and women. There is an association with Birt-Hogg-Dubé syndrome 4.
Pathology
This type of RCC arises from intercalated cells of collecting ducts 1,2. The designation "chromophobe" arises because the tumour cells are less translucent than clear cell renal cell carcinomas during staining for histology 1. They have a similar origin to oncocytomas 3.
Radiographic features
Ultrasound
- presents similarly to other renal cell masses, with an isoechoic/hypoechoic masslike contour abnormality and flow on colour Doppler imaging
CT
- relatively homogeneous contrast enhancement (less than the renal cortex).
MRI
- isointense to kidney / maybe T2 hypointense
- relatively homogeneous contrast enhancement
- necrosis not common
Differential diagnosis
- other subtypes of renal cell carcinoma
-
oncocytoma
- chromophobe RCC and oncocytoma share a similar pathologic origin and have similar imaging features
- the classic "spoke wheel pattern of enhancement in oncocytomas has been reported in chromophobe RCC 2
-<p><strong>Chromophobe renal cell carcinoma</strong> is one of the less common subtypes of <a href="/articles/renal-cell-carcinoma-1">renal cell carcinoma</a> (RCC).</p><h4>Epidemiology</h4><p>This is the least common major subtype of RCC, occurring 5% of the time <sup>1</sup>. Similar incidence in men and women. There is an association with <a href="/articles/birt-hogg-dube-syndrome-5">Birt-Hogg-Dubé syndrome</a> <sup>4</sup>.</p><h4>Pathology</h4><p>This type of RCC arises from intercalated cells of collecting ducts <sup>1,2</sup>. The designation "chromophobe" arises because the tumour cells are less translucent than clear cell renal cell carcinomas during staining for histology <sup>1</sup>. They have a similar origin to <a href="/articles/renal-oncocytoma">oncocytomas</a> <sup>3</sup>.</p><h4>Radiographic features</h4><h5>Ultrasound</h5><ul><li>presents similarly to other renal cell masses, with an isoechoic/hypoechoic masslike contour abnormality and flow on colour Doppler imaging</li></ul><h5>CT</h5><ul><li>relatively homogeneous contrast enhancement (less than the renal cortex).</li></ul><h5>MRI</h5><ul>-<li>isointense to kidney / maybe T2 hypointense</li>-<li>relatively homogeneous contrast enhancement</li>-<li>necrosis not common</li>-</ul><h4>Differential diagnosis</h4><ul>-<li>other subtypes of <a href="/articles/renal-cell-carcinoma-1">renal cell carcinoma</a><ul>-<li><a href="/articles/clear-cell-renal-cell-carcinoma">clear cell RCC</a></li>-<li><a href="/articles/papillary-renal-cell-carcinoma">papillary RCC</a></li>-</ul>-</li>-<li>-<a href="/articles/renal-oncocytoma">oncocytoma</a><ul>-<li>chromophobe RCC and <a href="/articles/renal-oncocytoma">oncocytoma</a> share a similar pathologic origin and have similar imaging features</li>-<li>the classic "spoke wheel pattern of enhancement in oncocytomas has been reported in chromophobe RCC <sup>2</sup>-</li>-</ul>-</li>- +<p><strong>Chromophobe renal cell carcinoma</strong> is one of the less common subtypes of <a href="/articles/renal-cell-carcinoma-1">renal cell carcinoma</a> (RCC).</p><h4>Epidemiology</h4><p>This is the least common major subtype of RCC, occurring 5% of the time <sup>1</sup>. Similar incidence in men and women. There is an association with <a href="/articles/birt-hogg-dube-syndrome-5">Birt-Hogg-Dubé syndrome</a> <sup>4</sup>.</p><h4>Pathology</h4><p>This type of RCC arises from intercalated cells of collecting ducts <sup>1,2</sup>. The designation "chromophobe" arises because the tumour cells are less translucent than clear cell renal cell carcinomas during staining for histology <sup>1</sup>. They have a similar origin to <a href="/articles/renal-oncocytoma">oncocytomas</a> <sup>3</sup>.</p><h4>Radiographic features</h4><h5>Ultrasound</h5><ul><li>presents similarly to other renal cell masses, with an isoechoic/hypoechoic masslike contour abnormality and flow on colour Doppler imaging</li></ul><h5>CT</h5><ul><li>relatively homogeneous contrast enhancement (less than the renal cortex).</li></ul><h5>MRI</h5><ul>
- +<li>isointense to kidney / maybe T2 hypointense</li>
- +<li>relatively homogeneous contrast enhancement</li>
- +<li>necrosis not common</li>
- +</ul><h4>Differential diagnosis</h4><ul>
- +<li>other subtypes of <a href="/articles/renal-cell-carcinoma-1">renal cell carcinoma</a><ul>
- +<li><a href="/articles/clear-cell-renal-cell-carcinoma">clear cell RCC</a></li>
- +<li><a href="/articles/papillary-renal-cell-carcinoma">papillary RCC</a></li>
- +</ul>
- +</li>
- +<li>
- +<a href="/articles/renal-oncocytoma">oncocytoma</a><ul>
- +<li>chromophobe RCC and <a href="/articles/renal-oncocytoma">oncocytoma</a> share a similar pathologic origin and have similar imaging features</li>
- +<li>the classic "spoke wheel pattern of enhancement in oncocytomas has been reported in chromophobe RCC <sup>2</sup>
- +</li>
- +</ul>
- +</li>
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