Chronic granulomatous disease (pulmonary manifestations)
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Pulmonary manifestations of chronic granulomatous disease can be seen in approximately 80% of cases of chronic granulomatous disease, which is a disease characterised by multiple bacterial and fungal infections occurring as a result of a defect in the gene that encodes NADPH oxidase.
The most common infectious agents include Aspergillus, Staphylococcus, Burkholderia, Nocardia and Serratia species.
Radiographic features
CT -
HRCT chest
Many features have been described which are variable and nonspecificnon-specific on their own.
These include 1,3:
- regions of consolidation
- pulmonary nodules
- regions of scarring
- emphysema
- traction bronchiectasis
- air trapping
- pulmonary arterial enlargement
- pleural effusions
- mediastinal and hilar lymphadenopathy
- empyema formation
Contiguous extension of disease from the lungs to the pleura or chest wall can be reported in up to one-third of patients 3.
-<p><strong>Pulmonary manifestations of chronic granulomatous disease</strong> can be seen approximately 80% of cases of <a href="/articles/chronic-granulomatous-disease">chronic granulomatous disease</a>, which is a disease characterised by multiple bacterial and fungal infections occurring as a result of a defect in the gene that encodes NADPH oxidase.</p><p>The most common infectious agents include <em><a href="/articles/aspergillus">Aspergillus</a>, Staphylococcus, Burkholderia, Nocardia</em> and <em>Serratia</em> species. </p><h4>Radiographic features</h4><h5>CT - HRCT chest</h5><p>Many features have been described which are variable and nonspecific on their own.</p><p>These include <sup>1,3</sup>:</p><ul>- +<p><strong>Pulmonary manifestations of chronic granulomatous disease</strong> can be seen in approximately 80% of cases of <a href="/articles/chronic-granulomatous-disease">chronic granulomatous disease</a>, which is a disease characterised by multiple bacterial and fungal infections occurring as a result of a defect in the gene that encodes NADPH oxidase.</p><p>The most common infectious agents include <em><a href="/articles/aspergillus">Aspergillus</a>, Staphylococcus, Burkholderia, Nocardia</em> and <em>Serratia</em> species. </p><h4>Radiographic features</h4><h5>CT</h5><h6>HRCT chest</h6><p>Many features have been described which are variable and non-specific on their own.</p><p>These include <sup>1,3</sup>:</p><ul>
-<li><a href="/articles/pulmonary-arterial-enlargement">pulmonary arterial enlargement</a></li>- +<li><a title="pulmonary artery enlargement" href="/articles/pulmonary-artery-enlargement">pulmonary arterial enlargement</a></li>
-</ul><p>Contiguous extension of disease from the lungs to the pleura or chest wall can be reported in up to one-third of patients <sup>3</sup>.</p><p> </p>- +</ul><p>Contiguous extension of disease from the lungs to the pleura or chest wall can be reported in up to one-third of patients <sup>3</sup>.</p>
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