The circumferential resection margin (CRM) is a term used in rectal carcinoma excision surgery (such as total mesorectal excision (TME)).
Pathologic evaluation of the resection margin on the excised rectum has been considered important for determining the risk of local recurrence. A margin of ≤1 mm is considered by some to be a negative prognostic factor for local recurrence 2.
The prognostic value of the CRM has been called into question in some recent studies 3. The CRM is not valid for excised colon covered by a peritoneal lining.
- 1. Nagtegaal ID, Quirke P. What is the role for the circumferential margin in the modern treatment of rectal cancer?. J. Clin. Oncol. 2008;26 (2): 303-12. doi:10.1200/JCO.2007.12.7027 - Pubmed citation
- 2. Park JS, Huh JW, Park YA et-al. A circumferential resection margin of 1 mm is a negative prognostic factor in rectal cancer patients with and without neoadjuvant chemoradiotherapy. Dis. Colon Rectum. 2014;57 (8): 933-40. doi:10.1097/DCR.0000000000000171 - Pubmed citation
- 3. Nikberg M, Kindler C, Chabok A et-al. Circumferential resection margin as a prognostic marker in the modern multidisciplinary management of rectal cancer. Dis. Colon Rectum. 2015;58 (3): 275-82. doi:10.1097/DCR.0000000000000250 - Pubmed citation