Clear cell ependymomas are a histological variant of ependymoma characterized by prominent perinuclear cytoplasmic clearing, reminiscent of oligodendrogliomas 1.
They are typically encountered in younger patients and usually in the supratentorial compartment 1.
They have a tendency to be quite vascular and may have a worse prognosis 1. RELA fusion-positive ependymomas are not infrequently of clear cell morphology 1.
- 1. Louis DN, Perry A, Reifenberger G et-al. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol. 2016;131 (6): 803-20. doi:10.1007/s00401-016-1545-1 - Pubmed citation