Clear cell tumors of the lung are rare benign pulmonary neoplasms that contain an abundant amount of glycogen. It is often classified under the spectrum of perivascular epithelioid cell tumors (PEComas).
Usually seen as a rounded, smooth-walled, and peripheral parenchymal nodule without cavitation or calcification. There is no recognized lobar distribution.
These tumors usually show intense post-contrast enhancement which is thought to be related to its rich vascular stroma 1,4.
History and etymology
It was initially described by A A Liebow and B Castleman in 1963 2.
- 1. Kim WJ, Kim SR, Choe YH et-al. Clear cell "sugar" tumor of the lung: a well-enhanced mass with an early washout pattern on dynamic contrast-enhanced computed tomography. J. Korean Med. Sci. 01;23 (6): 1121-4. doi:10.3346/jkms.2008.23.6.1121 - Free text at pubmed - Pubmed citation
- 2. Liebow AA, Castleman B. Benign clear cell ("sugar") tumors of the lung. Yale J Biol Med. 1971;43 (4-5): 213-22. Free text at pubmed - Pubmed citation
- 3. Seo JB, Im JG, Seo JW et-al. Clear cell tumor of the lung. AJR Am J Roentgenol. 1996;166 (3): 730-1. Pubmed citation
- 4. Santana AN, Nunes FS, Ho N et-al. A rare cause of hemoptysis: benign sugar (clear) cell tumor of the lung. Eur J Cardiothorac Surg. 2004;25 (4): 652-4. Eur J Cardiothorac Surg (full text) - doi:10.1016/j.ejcts.2004.01.022 - Pubmed citation
- 5. Adachi Y, Kitamura Y, Nakamura H et-al. Benign clear (sugar) cell tumor of the lung with CD1a expression. Pathol. Int. 2006;56 (8): 453-6. Pathol. Int. (full text) - doi:10.1111/j.1440-1827.2006.01988.x - Pubmed citation
- 6. Jordá aragón C, Froufe sánchez A, Padilla alarcón J. [Benign clear cell tumor of the lung]. Arch. Bronconeumol. 2005;41 (1): 59. Arch. Bronconeumol. (link) - Pubmed citation
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