Cleidocranial dysostosis

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Cleidocranial dysostosis (CCD) is a skeletal dysplasia with predominant membranous bone involvement. It carries an autosomal dominant inheritance ⁴.

Pathology

It is characterised by incomplete ossification of skeletal structures inclusive of the clavicle as well as defective development of the pubic bones, vertebral column, and long bones ⁵.

Clinical features

large head, with large fontenelles with delayed closure
broad mandible
supernumerary teeth
high arched palate
neonatal distress due to thorax being narrowed and bell shaped
excessively mobile shoulders
may have genu valgum and short fingers

Radiographic features

Plain film

Skull

wormian bones
widened sutures / fontanelles
premature fusion of the coronal suture (brachycephaly)
frontal / parietal bossing
basilar invagination (atlanto axial impaction)
persistent metopic suture

Chest

hypoplasia / aplasia of lateral clavicle (absent clavicles): may have two separate hypoplastic segments ⁵
supernumerary ribs
hemivertebrae with spondylosis
small and high scapulae

Pelvis

hypoplasia of iliac bones
absent / delayed ossification of the pubic bone (pseudo widening of the symphysis pubis)

Limbs

-<p><strong>Cleidocranial dysostosis (CCD)</strong> is a <a href="/articles/skeletal-dysplasia">skeletal dysplasia </a>with predominant membranous bone involvement. It carries an autosomal dominant inheritance <sup>4</sup>.</p><h4>Pathology</h4><p>It is characterised by incomplete ossification of skeletal structures inclusive of the clavicle as well as defective development of the pubic bones, vertebral column, and long bones <sup>5</sup>.</p><h4><strong>Clinical features</strong></h4><ul>
+<p><strong>Cleidocranial dysostosis (CCD)</strong> is a <a href="/articles/skeletal-dysplasia">skeletal dysplasia </a>with predominant membranous bone involvement. It carries an autosomal dominant inheritance <sup>4</sup>.</p><h4>Pathology</h4><p>It is characterised by incomplete ossification of skeletal structures inclusive of the clavicle as well as defective development of the pubic bones, vertebral column, and long bones <sup>5</sup>.</p><h4>Clinical features</h4><ul>
~~-</ul><h4><strong>Radiographic features</strong></h4><h5>Plain film</h5><h6>Skull</h6><ul>~~
+</ul><h4>Radiographic features</h4><h5>Plain film</h5><h6>Skull</h6><ul>

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Image 3 X-ray (Frontal) ( update )

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Case 3: adult

Updates to Synonym Attributes

Title was changed:

~~craniocleidodysostosis~~Craniocleidodysostosis

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