Revision 26 for 'Celiac disease'

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Celiac disease

Celiac disease also known as non tropical sprue 6 is a T cell mediated autoimmune chronic gluten intolerance condition characterized by loss of villi in the proximal small bowel and gastrointestinal malabsorption (sprue).

It should always be considered as a possible underlying etiology in cases of Iron deficiency anemia of uncertain cause.

Epidemiology

Celiac disease is relatively common in Caucasians, 1 in 200, but it is extremely rare in asians or black people. There are two peaks of presentation, small number of patients present early in childhood and the second more common group of patients presents at 3rd and 4th decade. 

Clinical presentation

Many patients have paucity of symptoms with no GI upset. However, abdominal pain is considered the most common symptoms. Other findings include:

  • iron deficiency anemia and guaiac-positive stools 
  • diarrhea
  • constipation
  • malabsorption including fat soluble vitamins
  • weight loss

Pathology

Celiac disease is a chronic autoimmune disease induced in genetically susceptible individuals after ingestion of gluten. Small bowel mucosa is primarily affected (submucosa, muscularis and serosa remain normal), resulting in progressive degrees of villous inflammation and destruction (which starts in duodenum and extends into ilium) with resulting of induction crypt hyperplasia. Loss of villi, which absorbs fluid, and hypertophy of crypts, which produce fluid , result in fluid excess in the small bowel lumen 8.  

The villous atrophy that occurs within the bowel also results in malabsorption of iron, folic acid, calcium and fat soluble vitamin resulting in a variety of signs, some of which may be non-specific.

The gold standard diagnostic test is a duodenal biopsy taken at UGIE. Histological features include total villous loss (initially blunting progressing to flattened mucosa). Additionally, serum antibodies may be raised:

  • anti-tissue transglutaminase antibody (anti-tTG), IgA
  • deamidated gliadin peptide (DGP) antibodies, IgA
  • anti-endomysial antibodies (EMA), IgA class
  • anti-reticulin antibodies (ARA), IgA class

Quantitative immunoglobulin A (IgA): measures the total level of IgA in the blood to determine if someone is deficient in the IgA class of antibodies. The IgG class of anti-tTG may be ordered for people who have a deficiency of IgA.

Associations

Radiographic features

Fluoroscopy (barium follow through)

Features of small bowel barium studies are not sensitive enough for confident diagnosis, but some changes may be seen:

CT enterocolysis

Features present on CT enterocolysis may include 3,6:

Complications

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