Congenital neuroblastoma

Last revised by Bahman Rasuli on 4 Dec 2020

Citation, DOI, disclosures and article data

Citation:

Gaillard F, Rasuli B, Jones J, et al. Congenital neuroblastoma. Reference article, Radiopaedia.org (Accessed on 20 Apr 2024) https://radiopaedia.org/articles/8360

DOI:

Permalink:

https://radiopaedia.org/articles/8360

rID:

8360

Article created:

25 Jan 2010, Frank Gaillard ◉ ◈

Disclosures:

At the time the article was created Frank Gaillard had no recorded disclosures.

View Frank Gaillard's current disclosures

Last revised:

4 Dec 2020, Bahman Rasuli ◉

Disclosures:

At the time the article was last revised Bahman Rasuli had no recorded disclosures.

View Bahman Rasuli's current disclosures

Revisions:

4 times, by 3 contributors - see full revision history and disclosures

Systems:

Paediatrics, Oncology

Tags:

adrenal gland, oncology, neonate

Congenital neuroblastoma is defined as neuroblastoma identified within a month of birth, and is divided into:

In most cases they present as stage 1, 2 or 4S (see neuroblastoma staging).

Fetal neuroblastoma

In 90% of cases, fetal neuroblastomas arise in the adrenal glands. They have been diagnosed as early as 19 weeks of gestation, but usually are seen in the third trimester (mean age of diagnosis 36 weeks) ¹.

In almost all cases the tumor undergoes maturation and regression, and prognosis is excellent with many institutions recommending conservative management ¹.

Neonatal neuroblastoma

Similarly neonatal neuroblastomas have much better prognosis than those found in older children with 90% being cured. In contrast to fetal neuroblastoma the adrenal glands are the site of tumor origin in only 45% of cases, and in ~ 60% of cases, metastases are present at the time of diagnosis. These are most frequently to the liver, which may be massively enlarged resulting in respiratory impairment ¹.