This is a basic article for medical students and other non-radiologists
COPD (chronic obstructive pulmonary disease) is defined as a condition characterized by persistent air flow limitation that is usually progressive and associated with an enhanced chronic inflammatory response in the airways and the lung to noxious particles or gases 1.
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Reference article
This is a summary article; read more in our article on COPD.
Terminology
The current definition of COPD does not include the terms chronic bronchitis or emphysema:
chronic bronchitis is defined as the presence of productive cough for three months in each of two successive years in a patient in whom other causes of chronic cough (e.g. bronchiectasis) have been excluded; patients with chronic bronchitis are not considered to have COPD unless they have airflow obstruction
emphysema is a pathological term defined as destruction of the alveoli walls; this is one of the structural abnormalities that can be present in patients with COPD but can also be found in persons with normal lung function 1
Summary
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epidemiology
highest prevalence among the over 60s
worldwide prevalence of approximately 10% 2
increased prevalence among men (approaching equality)
severe genetic form is seen in younger females
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presentation
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symptoms tend to be progressive
exertional dyspnea is the most common early symptom
chronic cough and sputum production
less commonly wheezing and chest tightness
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may present with
chronic daily respiratory symptoms
recurrent acute exacerbations
relatively little respiratory complaints but an extremely sedentary lifestyle due to the exertional dyspnea
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pathophysiology
most common risk factor is cigarette smoking
chronic irritants cause an inflammatory response in the respiratory tract which is amplified in COPD-prone patients
chronic inflammation leads to structural changes
changes occur predominantly in the peripheral airways but also in the large airways, lung parenchyma and pulmonary vasculature
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investigation
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spirometry
post-bronchidialtor FEV1/FVC ratio less than 0.7
in the absence of an alternative explanation for the symptoms and airflow limitation is diagnostic of COPD 1
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chest x-ray
exclude alternative diagnoses
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evaluate for co-morbidities
e.g. interstitial lung disease, lung cancer with airway obstruction
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in acute exacerbations, look for complicating processes
e.g. pneumonia, cardiac failure, pneumothorax
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treatment
smoking cessation
bronchodilators with or without inhaled corticosteroids
oxygen therapy may be required in severe cases
treatment of the underlying chest infection
Radiographic features
Chest radiograph
poor sensitivity to detect COPD
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possible findings include:
flattened diaphragm due to hyperexpansion
decreased peripheral bronchovascular markings
increased lung lucency (parenchymal loss)
bulla (round focal lucency over 1 cm)
prominence of the hilar vessels in pulmonary hypertension
CT chest
may determine the presence, pattern and extent of emphysema
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emphysema can be categorized as:
centrilobular emphysema: this is the most common type of smoking-related emphysema; it is called centrilobular because the destruction of parenchyma is centered around the terminal bronchiole, which is in the center of the secondary pulmonary lobule, and it tends to be more marked in the upper zones
panlobular emphysema: this type of emphysema is associated to alpha-1-antitrypsin deficiency but can also be seen in smoking-related emphysema, usually mixed with centrilobular emphysema; it is called panlobular because it affects all the areas of the lung lobule more or less equally
paraseptal emphysema: this term is used to describe emphysematous lesions in the parenchyma adjacent to the pleural surfaces
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other findings include
bronchial wall thickening
air trapping (small airway obstruction)
narrowing of the trachea in the coronal plane
pulmonary artery enlargement in pulmonary hypertension