Crossed cerebellar diaschisis
Updates to Article Attributes
Crossed cerebellar diaschisis (CCD) refers to a depression depression of blood flow and metabolism affecting the cerebellar hemisphere occurring as a result of a contralateral focal, supra-tentorial lesion (e.g. infarct, radiation necrosis, following a tumour resection).
Pathology
It is a well-recognized-recognised phenomenon following cerebral infarction. The most likely mechanism is thought to be interruption of cortico-ponto-cerebellarconnections-cerebellar connections due to the infarct which then causes deafferentation and transneuralmetabolictransneural metabolic depression of the contralateral cerebellar hemisphere
Radiographic features
Has to be interpreted in the correct clinical context.
CT / MRI and CT perfusion
CT perfusion performed during acute stroke may show a contralateral perfusion abnormality in about 20 % of cases 4. CBF and CBV maps show only mild to moderate reduction in the parameters and are never low to classify them as infarcts. There can be volume loss to the contra lateral cerebellar hemisphere.
FDG-PET
Shows hypometabolismhypo metabolism in affected cerebellar hemisphere 2.
-<p><strong>Crossed cerebellar diaschisis (CCD)</strong> refers to a depression of blood flow and metabolism affecting the cerebellar hemisphere occurring as a result of a contralateral focal, supra-tentorial lesion (e.g. infarct, radiation necrosis, following a tumour resection).</p><h4>Pathology</h4><p>It is a well-recognized phenomenon following cerebral infarction. The most likely mechanism is thought to be interruption of cortico-ponto-cerebellarconnections due to the infarct which then causes deafferentation and transneuralmetabolic depression of the contralateral cerebellar hemisphere</p><h4>Radiographic features</h4><p>Has to be interpreted in the correct clinical context. </p><h5>CT / MRI and CT perfusion</h5><p>CT perfusion performed during acute stroke may show a contralateral perfusion abnormality. CBF and CBV maps show only mild to moderate reduction in the parameters and are never low to classify them as infarcts. There can be volume loss to the contra lateral cerebellar hemisphere.</p><h5>FDG-PET</h5><p>Shows hypometabolism in affected cerebellar hemisphere <sup>2</sup>.</p>- +<p><strong>Crossed cerebellar diaschisis (CCD)</strong> refers to a depression of blood flow and metabolism affecting the cerebellar hemisphere occurring as a result of a contralateral focal, supra-tentorial lesion (e.g. infarct, radiation necrosis, following a tumour resection).</p><h4>Pathology</h4><p>It is a well-recognised phenomenon following cerebral infarction. The most likely mechanism is thought to be interruption of cortico-ponto-cerebellar connections due to the infarct which then causes deafferentation and transneural metabolic depression of the contralateral cerebellar hemisphere</p><h4>Radiographic features</h4><p>Has to be interpreted in the correct clinical context. </p><h5>CT / MRI and CT perfusion</h5><p>CT perfusion performed during acute stroke may show a contralateral perfusion abnormality in about 20 % of cases <sup>4</sup>. CBF and CBV maps show only mild to moderate reduction in the parameters and are never low to classify them as infarcts. There can be volume loss to the contra lateral cerebellar hemisphere.</p><h5>FDG-PET</h5><p>Shows hypo metabolism in affected cerebellar hemisphere <sup>2</sup>.</p>
References changed:
- 4. Förster A, Kerl HU, Goerlitz J et-al. Crossed cerebellar diaschisis in acute isolated thalamic infarction detected by dynamic susceptibility contrast perfusion MRI. PLoS ONE. 2014;9 (2): e88044. <a href="http://dx.doi.org/10.1371/journal.pone.0088044">doi:10.1371/journal.pone.0088044</a> - <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914872">Free text at pubmed</a> - <a href="http://www.ncbi.nlm.nih.gov/pubmed/24505372">Pubmed citation</a><span class="auto"></span>
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