Cyclopia refers to a rare fetal malformation characterized by a single palpebral fissure and a single midline orbit. This orbit may contain either a single globe or two separate globe.
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Epidemiology
The condition is thought to affect approximately 1 in 40,000 to 95,000 births (inclusive of stillbirths)
Pathology
It results from a deficient development of the superior precordial segment with an associated underdevelopment of the oro-nasal cavity 5. There is a severe error in prosencephalic development.
Associations
- proboscis
- severe brain malformations
Cyclopia can also occur as part of the spectrum of
Possible associations
Radiographic features
Antenatal ultrasound
May be seen with targeted imaging of the fetal face where a common orbit may be seen in the upper half of the face.
Prognosis
Cyclopia is essentially incompatible with life 1.
Etymology
Derived from the Greek word 'cyclopes' meaning 'ring-eyed' 4.