Diffuse small bowel disease may be caused by a number of conditions may be generalised multisystem disorders or conditions that effect the bowel in a global fashion:
- sprue
- scleroderma
- Whipple's disease
- amyloidosis
- hypoproteinaemia
- giardiasis
- intramural haemorrhage
- radiation enteritis
- small bowel lymphoma
- profound hypovolaemia - shock bowel