Diffuse T1 bone marrow signal loss

Last revised by Derek Smith on 7 Aug 2022

Diffuse T1 vertebral bone marrow signal loss is associated with replacement of fatty marrow by edema or cellular tissue. 

Radiographic features

MRI

T1-weighted imaging without fat suppression is one of the most important sequences for distinguishing between normal and abnormal bone marrow. Abnormal bone marrow is iso- or hypo-intense to skeletal muscle 3. In the case of homogeneous involvement, this appearance can often be difficult to spot as abnormal. 

Differential diagnosis

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