The term dolichoectasia means dilated and elongated. It is used to characterize arteries that have shown a significant deterioration of their tunica intima (and occasionally the tunica media), weakening the vessel walls and causing the artery to elongate and distend.

Dolichoectasias are more common in males 2. With intracranial dolichoectasia, the incidence is estimated at ~3% (range 0.06-5.8%) 2

Ischemic effects on the brain stem and cerebellar hemispheres as well as symptoms related to hydrocephalus are common. Direct cranial nerve compression can lead to isolated cranial nerve dysfunction, usually associated with a normal-sized basilar artery that is tortuous and elongated (neurovascular compression syndrome (NVCS)). Cranial nerve dysfunction most commonly involves the VII cranial nerve and the V cranial nerve. Multiple cranial nerve dysfunction is far more likely to occur if there is dilation (ectasia) associated with a tortuous and elongated basilar artery. Cranial nerves affected in descending order of frequency include VIIVIIIVIII, and VI.

As the arrangement of connective tissue is disturbed, the vessel wall is no longer able to hold its original conformation and begins to unravel due to the continued hypertension. High blood pressure molds and force the artery to take now on an elongated, tortuous course to better withstand the higher pressures.

Can be divided into several subtypes 3:

  • atherosclerotic dolichoectasia
  • non-atheroscerotic dolichoectasia
  • dolichoectatic appearance secondary to an arterial dissection

Hypertension most commonly causes the atherosclerotic type. Continued stress on the walls of the artery will degrade the vessel wall by damaging and loosening the collagen and elastin meshwork that comprises the intima. Similarly, hypercholesterolemia or hyperlipidemia can also provide sufficient trauma to the vessel wall resulting in dolichoectasia.

To be classified as dolichoectasia, in the vertebrobasilar system, the basilar arterial diameter should be >4.5 mm 1.

Internal carotid artery dolichoectasia is particularly interesting because the artery typically already contains one hairpin turn. Seen in an MRI as two individual arteries at this hairpin, a carotid artery dolichoectasia can progress so far as to produce a second hairpin turn and appear as three individual arteries on an MRI. The pathogenesis is primarily related to compression of the optic nerves at the optic chiasma. 

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Article information

rID: 5026
Synonyms or Alternate Spellings:
  • Dolichoectasia
  • Dolichoectasia: general

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Cases and figures

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  • Case 4: vertebrobasilar dolichoectasia
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  • Indentation and c...
    Case 5: vertebral artery
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