EGFR mutation
Updates to Article Attributes
AnEpidermal epidermal growth factor receptor (EGFR) mutation can may be expressed in a large proportion of non-small cell lung carcinomas (NSCLC). However, certain subtypes such as invasive mucinous adenocarcinoma of the lung can have very low expression.
The presence of this mutation can be assessed on biopsy samples. Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein that regulates signalling pathways to control cellular proliferation. It belongs to the erbB family of closely related-related receptor tyrosine kinases.
There is also some (but not 100% 5) mutual exclusivity with ALK gene arrangements.
Terminology
EGFR is not to be confused with the estimated glomerular filtration rate, which shares the same acronym but with a lower caselowercase "e": eGFR i.e. eGFR.
Clinical importance
Useful for assessing the suitability of certain anti-canceranticancer drugs (tyrosine(tyrosine kinase inhibitors) that inhibit EGFR such as gefitinib (IressaTM) ,erlotinib (TarcevaTM) and afatinib (GilotrifTM) 7.
See also
- KRAS mutation
- HER-2 mutations in lung cancer
- anaplastic lymphoma kinase (ALK) gene rearrangements
- ROS 1 mutation
Not to be confused with
- eGFR- (some e) similar abbreviation for - estimated glomerular filtration rate
-<p><strong>Epidermal growth factor receptor (<em>EGFR</em>) mutation</strong> can be expressed in a large proportion of <a href="/articles/non-small-cell-lung-cancer-3">non-small cell lung carcinomas (NSCLC)</a>. However, certain subtypes such as <a href="/articles/invasive-mucinous-adenocarcinoma-of-the-lung-1">invasive mucinous adenocarcinoma of the lung</a> can have very low expression.</p><p>The presence of this mutation can be assessed on biopsy samples. Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein that regulates signalling pathways to control cellular proliferation. It belongs to the erbB family of closely related receptor tyrosine kinases.</p><p>There is also some (but not 100% <sup>5</sup>) mutual exclusivity with <a href="/articles/anaplastic-lymphoma-kinase-alk-gene-rearrangements"><em>ALK</em> gene arrangements</a>.</p><h4>Terminology</h4><p>EGFR is not to be confused with the <a href="/articles/estimated-glomerular-filtration-rate">estimated glomerular filtration rate</a>, which shares the same acronym but with a lower case "e": eGFR. </p><h4>Clinical importance</h4><p>Useful for assessing the suitability of certain anti-cancer drugs (tyrosine kinase inhibitors) that inhibit EGFR such as gefitinib (Iressa<sup>TM</sup>) ,erlotinib (Tarceva<sup>TM</sup>) and afatinib (Gilotrif<sup>TM</sup>) <sup>7</sup>.</p><h4>See also</h4><ul>- +<p>An<strong> epidermal growth factor receptor (<em>EGFR</em>) mutation</strong> may be expressed in a large proportion of <a href="/articles/non-small-cell-lung-cancer-3">non-small cell lung carcinomas (NSCLC)</a>. However, certain subtypes such as <a href="/articles/invasive-mucinous-adenocarcinoma-of-the-lung-1">invasive mucinous adenocarcinoma of the lung</a> can have very low expression.</p><p>The presence of this mutation can be assessed on biopsy samples. Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein that regulates signalling pathways to control cellular proliferation. It belongs to the erbB family of closely-related receptor tyrosine kinases.</p><p>There is also some (but not 100% <sup>5</sup>) mutual exclusivity with <a href="/articles/anaplastic-lymphoma-kinase-alk-gene-rearrangements"><em>ALK</em> gene arrangements</a>.</p><h4>Terminology</h4><p>EGFR is not to be confused with the <a href="/articles/estimated-glomerular-filtration-rate">estimated glomerular filtration rate</a>, which shares the same acronym but with a lowercase "e" i.e. eGFR.</p><h4>Clinical importance</h4><p>Useful for assessing the suitability of certain anticancer drugs (<a title="tyrosine kinase inhibitors" href="/articles/tyrosine-kinase-inhibitors">tyrosine kinase inhibitors</a>) that inhibit EGFR such as gefitinib (Iressa<sup>TM</sup>) ,erlotinib (Tarceva<sup>TM</sup>) and afatinib (Gilotrif<sup>TM</sup>) <sup>7</sup>.</p><h4>See also</h4><ul>
-</ul><p>Not to be confused with</p><ul><li>-<strong>eGFR</strong> - (some e) similar abbreviation for - <a href="/articles/estimated-glomerular-filtration-rate">estimated glomerular filtration rate</a>- +</ul><p>Not to be confused with</p><ul><li>eGFR - (some e) similar abbreviation for - <a href="/articles/estimated-glomerular-filtration-rate">estimated glomerular filtration rate</a>
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