Endometrioid carcinoma of the endometrium is the most common histological subtype of endometrial carcinoma accounts for 85-90% of cases. It is considered a type I carcinoma of the uterus with slow progression and relatively good prognosis. Patients are usually 55 to 65 years old.
Endometrioid carcinoma are arising from precursor endometrial hyperplasia and associated with PTEN gene mutation in 30-90% of cases. They demonstrate well-defined glandular pattern resembling normal endometrial glands lined by malignant stratified columnar epithelial cells. Higher-grade endometrioid adenocarcinomas have undifferentiated cells with more solid sheets of tumor cells, which are not organized into well-defined glands and are associated with an atrophied endometrium.
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