Ependymal rosette corresponds to an histologic architectural pattern that provides strong evidence of ependymal differentiation (ependymoma). It is characterized by a halo or spoke-wheel arrangement of cells surrounding an empty tubule lumen.
It must be differentiated from:
- Homer Wright rosette: central lumen filled with fiber-like processes
- Flexner-Wintersteiner rosette: central lumen contains small cytoplasmic extensions of the encircling cells
- perivascular pseudorosette: cells surrounding a centrally native vessel
- pineocytomatous and neurocytic rosettes: generally larger and more irregular in contour