Revision 6 for 'Ependymal rosettes (ependymoma)'

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Ependymal rosettes (ependymoma)

Ependymal rosettes correspond to a histologic architectural pattern that very characteristic of ependymomas, as tumor cells form structures similar to the lining of normal ventricles. They are characterized by a halo or spoke-wheel arrangement of tumor cells surrounding an empty central tubule lumen.

They should not be confused with the far more common perivascular pseudorosette

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Differential diagnosis

In addition to perivascular pseudorosettes, an ependymal rosette should be differentiated from:

  • Homer Wright rosette: central lumen filled with fiber-like processes
  • Flexner-Wintersteiner rosette: central lumen contains small cytoplasmic extensions of the encircling cells
  • pineocytomatous and neurocytic rosettes:  generally larger and more irregular in contour

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