Extranodal extension

Extranodal extension refers to the growth of a nodal cancer metastasis beyond the confines of the capsule of the lymph node into adjacent tissues. Less preferred synonyms include extranodal spread, extracapsular extension, or extracapsular spread. This finding holds prognostic implications. For example, in the latest TNM staging system for most cancers of the head and neck, extranodal extension is the most significant pathological finding in a positive lymph node. For staging purposes, a regional node metastasis invading a distant organ is considered an extranodal extension and not distant metastatic disease 1.

Share article

Article information

rID: 66438
System: Haematology
Section: Pathology
Synonyms or Alternate Spellings:
  • Extranodal spread
  • Extracapsular spread
  • Extracapsular extension

Support Radiopaedia and see fewer ads

Updating… Please wait.

 Unable to process the form. Check for errors and try again.

 Thank you for updating your details.