Fleischner Society pulmonary nodule recommendations

The Fleischner Society pulmonary nodule recommendations pertain to the follow-up and management of indeterminate pulmonary nodules detected incidentally on CT. The guideline does not apply to lung cancer screening, patients younger than 35 years, or patients with a history of primary cancer or immunosuppression. This article reflects the 2017 revision 4, which supersedes prior versions published in 2005 1 and 2013 2.

  • low-risk patients: no routine follow-up required
  • high-risk patients: optional CT at 12 months (particularly with suspicious nodule morphology and/or upper lobe location; see "risk sssessment" below)
  • low-risk patients: CT at 6-12 months, then consider CT at 18-24 months
  • high-risk patients: CT at 6-12 months, then if persistent, CT at 18-24 months
  • consider CT at 3 months, PET/CT, or tissue sampling
  • low-risk patients: no routine follow-up required
  • high-risk patients: optional CT at 12 months
  • low-risk patients: CT at 3-6 months, then consider CT at 18-24 months
  • high-risk patients: CT at 3-6 months, then if persistent, CT at 18-24 months

When multiple nodules are persistent, the dominant/most suspicious nodule should guide further individualized management.

  • no routine follow-up required
  • CT at 6-12 months, then if persistent CT every 2 years until 5 years
  • CT at 3-6 months, then if persistent and solid component remains <6 mm, annual CT until 5 years
  • CT at 3-6 months, then if stable consider CT at 2 and 4 years in high risk patients
  • CT at 3-6 months, then subsequent management based on the most suspicious nodule(s)

Certain technical parameters for imaging nodules have been recommended 5,6:

  • image production and viewing
    • images should be acquired in full inspiration
    • nodules should usually be measured in the axial (transverse) plane, although the coronal or sagittal plane may be used if the greatest dimensions lie in those planes
    • nodules should be measured in lung windows, although soft tissue windows can help evaluate changes in nodule density over time
    • small nodules (<10 mm) should be viewed and measured on images reconstructed in thin slices (≤1.5 mm) using a high-spatial frequency (sharp) algorithm, in order to avoid partial volume averaging and identify fat or calcified components
  • nodule description and assessment
    • by size
      • small nodules 3-10 mm should be expressed, for risk estimation purposes, as the average of the short-axis and long-axis diameters
      • small nodules <3 mm should not be measured and should be described as micronodules
      • larger nodules >10 mm and masses, for descriptive purposes, should be described in both short- and long-axis measurements
    • measurements should be rounded to the nearest whole millimeter
    • part solid nodules
      • solid components over 3 mm should have the maximal diameter reported
      • part solid nodules cannot be discerned as such under 6 mm
    • when multiple nodules are present, only the largest or morphologically most suspicious need to be measured and have their location(s) reported
    • an increase in nodule dimension of 2 mm or more is required to identify significant growth
  • patients aged 35 years or younger
    • considered to have an overall low risk for malignancy pulmonary
    • in this age group, nodules are most likely to be infectious than cancer
    • management of incidentally found pulmonary nodules in this group should be individualised
  • patients with known malignancy
    • an incidentally detected pulmonary nodule is more likely to be cancer-related that in the general population
  • immunocompromised patients
    • higher risk for opportunistic pulmonary infections
  • lung cancer screening population
    • these patients are on active screening for being high-risk for lung cancer development, usually current and former smokers, and, therefore, should have their scans reported accordingly to Lung-RADS
  • thick-slice scans (>2 mm thickness)
    • although the revised 2017 guideline does not approach this scenario, some authors advise that for nodules larger ≥6 mm, a complete thin-slice CT of the chest should be recommended as early as possible to further determine an accurate management 5
  • incomplete CT scans (e.g. abdomen and neck scans)
    • ≦8 mm nodules should follow the guideline
    • >8 mm nodules or those with very suspicious features need further complete chest CT as early as possible 4,5

Because some categories are stratified by low and high risk (e.g. for solitary solid pulmonary nodules <6 mm), clinicians are asked to assess the risk of malignancy using factors other than the nodule descriptors included in the guidelines (size, multiplicity, and attenuation). The guidelines recommend considering high-risk as estimated risk of cancer >5%.

Suggested risk factors to consider include older age, heavy smoking, irregular or spiculated margins, and upper lobe location. There is considerable ambiguity in the guidelines regarding this task, affording radiologists and other clinicians significant flexibility for tailoring recommendations to the individual clinical scenario and imaging findings. According to the American College of Chest Physicians, risk assessment can be performed qualitatively by using one's clinical judgment and/or quantitatively by using a validated model 7.

When multiple nodules are detected and persistent on the follow-up scan, the most suspicious nodule should guide further management. Suspicious imaging features to consider include interval growth of a solid component that is 6 mm or larger, spiculated margins, interval increase in density, or a new microcystic component 5.  Persistent part solid nodules with solid components ≥6 mm should also be considered highly suspicious. The presence of these features may prompt further diagnostic evaluation rather than continued follow-up according to these guidelines.

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Article information

rID: 13541
System: Chest
Section: Approach
Synonyms or Alternate Spellings:
  • Fleischner society recommonedations for pulmonary nodule assessment

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