Focal lymphoid hyperplasia of the lung

Focal lymphoid hyperplasia of the lung refers to an abnormal accumulation of non-malignant lymphocytic aggregates within the lung. 

Previously known as pulmonary pseudolymphoma.

Clinical features can vary from being asymptomatic to various symptoms such as wheeze, shortness of breath, chest pain and cough.

They can be solitary or multifocal 1. It is considered a hyperplastic condition. There can be dense alveolar and peribronchial infiltration by numerous mature lymphocytes and plasma cells surrounding reactive lymphoid follicles with true germinal centers within the lung.

Histologically there can be similarities with lymphocytic interstitial pneumonia.

There can be a range of imaging manifestations. Typically it is seen as a solitary nodule or a focal area of consolidation 8. Multiple lesions may be seen and lesions span several centimeters in diameter.

They are mostly benign but can be difficult to differentiate from more sinister conditions. They can, however, rarely develop into malignant lymphoma.


Article information

rID: 23065
System: Oncology, Chest
Synonyms or Alternate Spellings:
  • Pulmonary pseudolymphomas
  • Pseudolymphoma of lung
  • Non malignant lymphocytic pulmonary infiltrates
  • Non malignant lymphocytic infiltrates in lungs
  • Pulmonary pseudolymphoma
  • Focal lymphoid hyperplasia of lung
  • Focal lymphoid hyperplasia of the lungs

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