Gallbladder agenesis

Changed by Henry Knipe, 17 Jun 2014

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Agenesis of gallbladder is a rare congenital anomaly.

Epidemiology

Incidence is <0.1% (range 0.04-0.1%). There is strong female predominace present among the symptomatic cases.

Clinical presentation

Most of the patients with agenesis of the gallbladder are asymptomatic. Although some patients may present with signs and symptoms of gallbladder disease and ultrasound may suggest findings consistent with chronic cholecystitis (shrunken gallbladder). Jaundice may be present with dilated CBDcommon bile duct. There is high incidence of choledocholithiasis.

Pathology

Exact etiologyaetiology is unknown, however it is thought to result either from failure of cystic bud to form or from lack of vacuolation. Several cases of familial gallbladder agenesis have also been reported, suggesting a heriditaryhereditary basis of the anomaly.

Associations

Agenesis of gallbladder is associated with several other anomalies:

  • -<p><strong>Agenesis of gallbladder</strong> is a rare congenital anomaly.</p><h4>Epidemiology</h4><p>Incidence is &lt;0.1% (range 0.04-0.1%). There is strong female predominace present among the symptomatic cases.</p><h4>Clinical presentation</h4><p>Most of the patients with agenesis of the gallbladder are asymptomatic. Although some patients may present with signs and symptoms of gallbladder disease and ultrasound may suggest findings consistent with <a href="/articles/chronic-cholecystitis">chronic cholecystitis</a> (shrunken gallbladder). <a title="Jaundice" href="/articles/jaundice">Jaundice</a> may be present with dilated CBD. There is high incidence of <a href="/articles/choledocholithiasis">choledocholithiasis</a>.</p><h4>Pathology</h4><p>Exact etiology is unknown, however it is thought to result either from failure of cystic bud to form or from lack of vacuolation. Several cases of familial gallbladder agenesis have also been reported, suggesting a heriditary basis of the anomaly.</p><h5>Associations</h5><p>Agenesis of gallbladder is associated with several other anomalies:</p><ul>
  • +<p><strong>Agenesis of gallbladder</strong> is a rare congenital anomaly.</p><h4>Epidemiology</h4><p>Incidence is &lt;0.1% (range 0.04-0.1%). There is strong female predominace present among the symptomatic cases.</p><h4>Clinical presentation</h4><p>Most of the patients with agenesis of the gallbladder are asymptomatic. Although some patients may present with signs and symptoms of gallbladder disease and ultrasound may suggest findings consistent with <a href="/articles/chronic-cholecystitis">chronic cholecystitis</a> (shrunken gallbladder). <a href="/articles/jaundice">Jaundice</a> may be present with dilated <a title="Common bile duct" href="/articles/common-bile-duct">common bile duct</a>. There is high incidence of <a href="/articles/choledocholithiasis">choledocholithiasis</a>.</p><h4>Pathology</h4><p>Exact aetiology is unknown, however it is thought to result either from failure of cystic bud to form or from lack of vacuolation. Several cases of familial gallbladder agenesis have also been reported, suggesting a hereditary basis of the anomaly.</p><h5>Associations</h5><p>Agenesis of gallbladder is associated with several other anomalies:</p><ul>

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