Revision 10 for 'Gallbladder agenesis'

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Gallbladder agenesis

Agenesis of gallbladder is a rare congenital anomaly.


Incidence is <0.1% (range 0.04-0.1%). There is strong female predominace present among the symptomatic cases.

Clinical presentation

Most of the patients with agenesis of the gallbladder are asymptomatic. Although some patients may present with signs and symptoms of gallbladder disease and ultrasound may suggest findings consistent with chronic cholecystitis (shrunken gallbladder). Jaundice may be present with dilated common bile duct. There is high incidence of choledocholithiasis.


Exact etiology is unknown, however it is thought to result either from failure of cystic bud to form or from lack of vacuolation. Several cases of familial gallbladder agenesis have also been reported, suggesting a hereditary basis of the anomaly.


Gallbladder agenesis is associated with several other anomalies:

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