Revision 2 for 'Gallbladder dysfunction'

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Gallbladder dysfunction

Gallbladder dysfunction, or functional gallbladder disorder, refers to biliary pain due to motility disturbance of the gallbladder without gallstones, biliary sludge, microlithiasis or microcrystals. The disorder has previous been known by several other names, including gallbladder dyskinesia, gallbladder dysmotility, chronic acalculous cholecystitis, acalculous cholecystitis, and cystic duct syndrome.


An estimated 8% of men and 21% of women who report biliary pain have normal gallbladder ultrasound scans, and 20-25% of cholecystectomies performed in recent years have been for gallbladder dysfunction.3,4

Clinical presentation

Patients commonly present with recurrent episodic biliary pain, typically described as right upper quadrant or epigastric pain that can radiate to the back or right shoulder. The pain can be associated with nausea, vomiting and sweating. Episodes typically last for between 30 minutes to six hours. An association with meals, particularly fatty meals, is common but not always a feature.1,2 There are usually normal results for common laboratory investigations for workup of biliary pain, including bilirubin, ALT, ALP, GGT, and lipase.


The underlying etiology of the disturbance to gallbladder motility is incompletely understood. Associations with obesity, other gastro-intestinal tract motility disorders, and abnormalities of bile composition have been suggested.1,2

Radiographic features


Ultrasound is typically performed as the modality of choice for investigation of biliary pain. In gallbladder dysfunction, ultrasound examination of the gallbladder is usually normal, with no cholelithiasis, biliary sludge, thickened gallbladder wall or hyperemia.



Treatment and prognosis


Differential diagnosis


Practical points

  • diagnosis of exclusion in patients with biliary pain; firstly exclude other causes
  • cholescintigraphy can confirm the diagnosis, with a low ejection fraction

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