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Gardner syndrome

Gardner syndrome is one of the polyposis syndromes. It is characterized by:

Other abnormalities include:


There is an autosomal dominant inheritance in the FAP gene (chromosome 5q) in a majority of patients but with 20% of cases resulting from new mutations. Extracolonic features often precede the diagnosis of colonic polyps. 

History and etymology

First described in 1953 by Gardner and Richards 3.

Article information

rID: 1370
Synonyms or Alternate Spellings:
  • Gardner's syndrome

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Cases and figures

  • Case 1: duodenal polyps and osteomas, proven syndrome
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  • Case 2: multiple osteomas and supernumerary teeth
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  • Case 3
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  • Case 4: after total colectomy
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