Radiologically, this term is used quite loosely to refer to a calcified granuloma; technically, the Ghon lesion is the initial tuberculous granuloma formed during primary infection and is not radiologically visible unless it calcifies - this occurs in up to 15% of cases 4.
A Ghon focus alongside ipsilateral mediastinal lymphadenopathy is known as a Ghon complex. A calcified Ghon complex (Ghon lesion and ipsilateral lymph node) is called a Ranke complex, which is radiologically detectable. Thus the Ranke complex represents a progression of the Ghon complex, rather than being a separate entity in itself 4.
History and etymology
Anton Ghon (1866-1936) was an Austrian pathologist who spent his life researching tuberculosis and meningitis 3.
- 1. Collins J, Stern EJ. Chest Radiology. Lippincott Williams & Wilkins. (2008) ISBN:0781763142. Read it at Google Books - Find it at Amazon
- 2. Grainger's and Allison's Diagnostic Radiology. Churchill Livingstone. (2008) ISBN:0443101639. Read it at Google Books - Find it at Amazon
- 3. Ober WB. Ghon but not forgotten: Anton Ghon and his complex. Pathology annual. 18 Pt 2: 79-85. Pubmed
- 4. Joshua Burrill, Christopher J. Williams, Gillian Bain, Gabriel Conder, Andrew L. Hine, Rakesh R. Misra. Tuberculosis: A Radiologic Review1. (2007) RadioGraphics. 27 (5): 1255-73. doi:10.1148/rg.275065176 - Pubmed
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