Giant cell interstitial pneumonia
Last revised by Daniel J Bell on 4 Nov 2021
Citation, DOI, disclosures and article data
Citation:
Weerakkody Y, Bell D, Murphy A, et al. Giant cell interstitial pneumonia. Reference article, Radiopaedia.org (Accessed on 19 Apr 2024) https://doi.org/10.53347/rID-20953
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rID:
20953
Article created:
23 Dec 2012,
Yuranga Weerakkody ◉
Disclosures:
At the time the article was created Yuranga Weerakkody had no recorded disclosures.
View Yuranga Weerakkody's current disclosures
Last revised:
4 Nov 2021,
Daniel J Bell ◉
Disclosures:
At the time the article was last revised Daniel J Bell had no recorded disclosures.
View Daniel J Bell's current disclosures
Revisions:
8 times, by
6 contributors -
see full revision history and disclosures
Systems:
Tags:
Synonyms:
- Giant cell interstitial pneumonias
- Giant cell interstitial pneumonia (GIP)
- Giant cell interstitial pneumonitis
Giant cell interstitial pneumonia is a rare form of pulmonary fibrosis. It is currently considered a form of pneumoconiosis and in many situations is caused by exposure to metal compounds such as cobalt or tungsten carbide.
On this page:
Terminology
While some authors consider this term to be synonymous with or being almost pathognomonic of hard metal pneumoconiosis 5,7, there are certain situations where giant cell interstitial pneumonia is idiopathic and not associated with exposure to hard metal compounds 2,3.
Epidemiology
Associations
- exposure to hard metal compounds: strong
- nitrofurantoin: possible 6
Pathology
Giant cell interstitial pneumonia is characterized by the prominence of large, actively phagocytic alveolar giant cells of histiocytic origin in the presence of chronic interstitial pneumonia. Multinucleated type 2 granular pneumocytes may also be present 2.
References
- 1. Choi JW, Lee KS, Chung MP et-al. Giant cell interstitial pneumonia: high-resolution CT and pathologic findings in four adult patients. AJR Am J Roentgenol. 2005;184 (1): 268-72. AJR Am J Roentgenol (full text) - Pubmed citation
- 2. Daroca PJ, George WJ. Giant cell interstitial pneumonia. South. Med. J. 1991;84 (2): 257-63. Pubmed citation
- 3. Menon B, Sharma A, Kripalani J et-al. Giant cell interstitial pneumonia in a 60-year-old female without hard metal exposure. Respiration.;73 (6): 833-5. Respiration (abstract) - doi:10.1159/000091610 - Pubmed citation
- 4. Tabatowski K, Roggli VL, Fulkerson WJ et-al. Giant cell interstitial pneumonia in a hard-metal worker. Cytologic, histologic and analytical electron microscopic investigation. Acta Cytol. 1988;32 (2): 240-6. Pubmed citation
- 5. Ohori NP, Sciurba FC, Owens GR et-al. Giant-cell interstitial pneumonia and hard-metal pneumoconiosis. A clinicopathologic study of four cases and review of the literature. Am. J. Surg. Pathol. 1989;13 (7): 581-7. Pubmed citation
- 6. Hargett CW, Sporn TA, Roggli VL et-al. Giant cell interstitial pneumonia associated with nitrofurantoin. Lung. 2006;184 (3): 147-9. Lung (full text) - doi:10.1007/s00408-005-2574-z - Pubmed citation
- 7. Nemery B, Verbeken EK, Demedts M. Giant cell interstitial pneumonia (hard metal lung disease, cobalt lung). Semin Respir Crit Care Med. 2005;22 (04): 435-48. doi:10.1055/s-2001-17386 - Pubmed citation
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