Glioblastoma NOS
Citation, DOI, disclosures and article data
At the time the article was created Frank Gaillard had no recorded disclosures.
View Frank Gaillard's current disclosuresAt the time the article was last revised Henry Knipe had the following disclosures:
- Integral Diagnostics, Shareholder (ongoing)
- Micro-X Ltd, Shareholder (ongoing)
These were assessed during peer review and were determined to not be relevant to the changes that were made.
View Henry Knipe's current disclosuresGlioblastoma NOS (not otherwise specified) is a diagnosis in the current (2021) WHO classification of CNS tumors and denotes a diffuse glioma with astrocytic features and anaplasia, microvascular proliferation and/or necrosis consistent with a WHO grade 4 tumor but with inconclusive or unavailable IDH mutation status 1,2.
As such, much of the older literature on glioblastomas should be considered to describe glioblastoma NOS.
As most glioblastoma NOS are in actuality glioblastoma IDH wild-type (just with unavailable IDH status), they are discussed as part of the main glioblastoma article.
Quiz questions
References
- 1. Louis DN, Ohgaki H, Wiestler OD et-al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 2007;114 (2): 97-109. Acta Neuropathol. (full text) - doi:10.1007/s00401-007-0243-4 - Free text at pubmed - Pubmed citation
- 2. Louis D, Perry A, Wesseling P et al. The 2021 WHO Classification of Tumors of the Central Nervous System: A Summary. Neuro-Oncology. 2021;23(8):1231-51. doi:10.1093/neuonc/noab106 - Pubmed
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- Glioblastoma NOS
- Corpus callosum glioblastoma
- Glioblastoma, IDH-wildtype
- High grade glioma, NOS grade 4
- Glioblastoma NOS
- Glioblastoma (NOS)
- Intracerebral metastasis of glioblastoma multiforme
- Glioblastoma
- Glioblastoma NOS
- Glioblastoma NOS
- Glioblastoma NOS
- Glioblastoma NOS
- Glioblastoma NOS
- Glioblastoma NOS
- Glioblastoma NOS
- Glioblastoma NOS
- Glioblastoma NOS (multicentric)
- Glioblastoma
- Glioblastoma NOS
- Glioblastoma - recurrent
Related articles: Astrocytic tumour
-
astrocytic tumors
- WHO classification of CNS tumors
- WHO grading of CNS tumors
- VASARI MRI feature set
- diffuse astrocytoma grading
- grade I:
- grade II:
- chordoid glioma of the third ventricle
-
low-grade diffuse astrocytoma
- fibrillary astrocytoma (no longer recognized)
- protoplasmic astrocytoma (no longer recognized)
- gemistocytic astrocytoma
- oligoastrocytoma (no longer recognized)
- pilomyxoid astrocytoma
- pleomorphic xanthoastrocytoma
- grade III
- anaplastic astrocytoma (no longer recognized)
- anaplastic oligoastrocytoma (no longer recognized)
- anaplastic pleomorphic xanthoastrocytoma (no longer recognized)
- grade IV:
-
glioblastoma (GBM)
- glioblastoma IDH wildtype
- glioblastoma IDH mutant
- glioblastoma NOS
- variants
- diffuse midline glioma H3 K27M–mutant
-
glioblastoma (GBM)
- glioblastoma vs cerebral metastasis
- radiation-induced gliomas
- gliomatosis cerebri (growth pattern)
- specific locations
- treatment response
- prognostic genetic markers
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