Head and neck cancer therapy response interpretation (Hopkins criteria)
The head and neck cancer therapy response interpretation (Hopkins criteria) is a qualitative system of interpretation for therapy response assessment using PET-CT.
Widely used options for therapy response assessment are clinical examination, histopathology, CT and MR imaging, however, they have variable diagnostic accuracy 1,2. 18F-FDG PET-CT is useful in the diagnosis, staging, therapy assessment, and follow-up of head and neck squamous cell carcinoma (HNSCC) 3,4. Pretreatment 18F-FDG PET-CT is useful in accurate staging and prediction of disease recurrence as well as survival 5. Post-treatment 18F-FDG PET-CT is useful in evaluating treatment response, detecting recurrence 6, predicting outcomes and survival 7,8.
These criteria have substantial interreader agreement, high negative predictive value, and can predict overall survival and progression-free survival in patients with HNSCC 9.
Five-point qualitative post-therapy assessment scoring system (Hopkins criteria) for head and neck PET-CT:
- Response category 18F-FDG uptake at the primary site and nodes less than internal jugular vein (IJV). Complete metabolic response.
- Focal 18 F-FDG uptake at the primary site and nodes greater than IJV but less than liver. Likely complete metabolic response.
- Diffuse 18 F-FDG uptake at the primary site or nodes is greater than IJV or liver. Likely postradiation inflammation.
- Focal 18 F-FDG uptake at the primary site or nodes greater than liver. Likely residual tumor.
- Focal and intense 18 F-FDG uptake at the primary site or nodes. Residual tumor.
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