Hepatomegaly
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Hepatomegaly (an refers to an increase in size or enlargement of the liver size).
Pathology
Aetiology
Hepatomegaly can result from a vast range of pathologies pathology including, but not limited to, the following:
-
malignancy
/ cellular/cellular infiltrate -
acquired hepatic conditions
- fatty infiltration
- cirrhosis - early
- secondary haemochromatosis
- hepatic amyloidosis
- hepatic veno-occlusive disease
- sarcoidosis
- infectious mononucleosis
- primary biliary cirrhosis
- acquired non hepatic conditions
-
congenital anomalies
-
biochemical
- glycogen storage disease
- primary haemochromatosis
- Gaucher's disease
- certain mucopolysaccharidoses
:- e.g. Hunter syndrome - Niemann-Pick disease
- anatomical
-
biochemical
- syndromes
Radiographic features
Assessment of liver size in commonly made on ultrasound or CT, although gross hepatomegaly may be apparent on plain film imaging.
A liver that is longer than 15.5cm in the mid-clavicular line is considered enlarged, however in practice assessment is often subjective. FeaturesFeatures that support hepatomegaly include extension1:
-
extension of the right lobe inferior to the lower pole of the right kidney
and rounding -
rounding of the hepatic inferior border
1.
Differential diagnosis
- Riedel's lobe (normal variant)
See also
-<p><strong>Hepatomegaly</strong> (an increase in <a title="liver" href="/articles/liver">liver</a> size) can result from a vast range of pathologies :</p><ul>- +<p><strong>Hepatomegaly</strong> refers to an increase in size or enlargement of the <a href="/articles/liver">liver</a>. </p><h4>Pathology</h4><h5>Aetiology</h5><p>Hepatomegaly can result from a vast range of pathology including, but not limited to, the following:</p><ul>
-<strong>malignancy / cellular infiltrate</strong><ul>- +<strong>malignancy/cellular infiltrate</strong><ul>
-<a href="/articles/cirrhosis">cirrhosis </a>: early</li>- +<a href="/articles/cirrhosis">cirrhosis</a> - early</li>
-<li>certain <a href="/articles/mucopolysaccharidoses-2">mucopolysaccharidoses</a> : e.g. <a href="/articles/hunter-syndrome">Hunter syndrome</a>- +<li>certain <a href="/articles/mucopolysaccharidoses-2">mucopolysaccharidoses</a> - e.g. <a href="/articles/hunter-syndrome">Hunter syndrome</a>
-</ul><h4>Radiographic features</h4><p>Assessment of liver size in commonly made on ultrasound or CT, although gross hepatomegaly may be apparent on plain film imaging.</p><p>A liver that is longer than 15.5cm in the mid-clavicular line is considered enlarged, however in practice assessment is often subjective. Features that support hepatomegaly include extension of the right lobe inferior to the lower pole of the right kidney and rounding of the hepatic inferior border<sup>1</sup>.</p><h4>Differential diagnosis</h4><ul><li>- +</ul><h4>Radiographic features</h4><p>Assessment of liver size in commonly made on ultrasound or CT, although gross hepatomegaly may be apparent on plain film imaging.</p><p>A liver that is longer than 15.5cm in the mid-clavicular line is considered enlarged, however in practice assessment is often subjective. Features that support hepatomegaly include <sup>1</sup>:</p><ul>
- +<li>extension of the right lobe inferior to the lower pole of the right <a title="Kidney anatomy" href="/articles/kidneys">kidney</a>
- +</li>
- +<li>rounding of the hepatic inferior border</li>
- +</ul><h4>Differential diagnosis</h4><ul><li>
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Image 6 X-ray (Frontal) ( create )
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