HER-2 mutations in lung cancer

Last revised by Roland Warner on 27 Nov 2019

Citation, DOI, disclosures and article data

Citation:

Weerakkody Y, Warner R, Bell D, HER-2 mutations in lung cancer. Reference article, Radiopaedia.org (Accessed on 10 May 2024) https://doi.org/10.53347/rID-69172

DOI:

https://doi.org/10.53347/rID-69172

Permalink:

https://radiopaedia.org/articles/69172

rID:

69172

Article created:

1 Jul 2019, Yuranga Weerakkody ◉

Disclosures:

At the time the article was created Yuranga Weerakkody had no recorded disclosures.

View Yuranga Weerakkody's current disclosures

Last revised:

27 Nov 2019, Roland Warner

Disclosures:

At the time the article was last revised Roland Warner had no recorded disclosures.

View Roland Warner's current disclosures

Revisions:

3 times, by 3 contributors - see full revision history and disclosures

Systems:

Chest, Oncology

Sections:

Pathology

Synonyms:

Human epidermal growth factor receptor 2 (HER-2) mutations in lung cancer
Human epidermal growth factor receptor 2 mutations in lung cancer

Human epidermal growth factor receptor 2 (HER-2) mutations may be detected in approximately 3% of lung adenocarcinomas ¹.

Radiographic features

CT

Early studies have suggested HER2-mutant tumours exhibit more aggressive features in general and tend to:

exhibit a locally-invasive behaviour compared with KRAS-mutant tumours ³
show preponderance for pleural retractions compared with KRAS- and EGFR-mutant tumours ³
present with greater nodal metastatic spread compared KRAS-mutant tumours³