Heyde syndrome is an association between aortic valve stenosis and gastrointestinal hemorrhage.
The etiology of the gastrointestinal bleeding in this setting is uncertain, but it is thought to be related to intestinal angiodysplasia. The strength of this association independent of age-related degeneration has been debated. Others suggest that an acquired von Willebrand syndrome (type 2A) associated with aortic valve stenosis is the etiology of the patients' bleeding 3.
Aortic valve replacement may decrease the risk of hemorrhage 4.
History and etymology
It was first described by E Heyde in 1958.
- 1. E.C. Heyde, Gastrointestinal bleeding in aortic stenosis [letter]. N Engl J Med, 259 (1958), p. 196. [No pubmed ID]
- 2. Sucker C. The Heyde syndrome: proposal for a unifying concept explaining the association of aortic valve stenosis, gastrointestinal angiodysplasia and bleeding. Int. J. Cardiol. 2007;115 (1): 77-8. doi:10.1016/j.ijcard.2006.01.014 - Pubmed citation
- 3. Vincentelli A, Susen S, Le Tourneau T et-al. Acquired von Willebrand syndrome in aortic stenosis. N. Engl. J. Med. 2003;349 (4): 343-9. doi:10.1056/NEJMoa022831 - Pubmed citation
- 4. Thompson JL, Schaff HV, Dearani JA et-al. Risk of recurrent gastrointestinal bleeding after aortic valve replacement in patients with Heyde syndrome. J. Thorac. Cardiovasc. Surg. 2012;144 (1): 112-6. doi:10.1016/j.jtcvs.2011.05.034 - Pubmed citation