Honeycombing (lungs)
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Honeycombing refers to the computed tomographic (CT) manifestation of diffuse pulmonary fibrosis (usual interstitial pneumonia). CT demonstrates The Fleischner Society definition is clustered cystic air spaces (between 0.3-1.0 cm3-10mm in diameter but occasionally as large as 2.5 cm), which are usually subpleural and basal in distribution. The walls of the cysts are well-defined and often thick (1-3 mm) 4). Honeycombing
Honeycombing is an irreversible finding ininterstitial lung lung disease and associated with a poor prognosis.
Pathology
Honeycombing consists of enlarged airspaces with thick fibrotic wall lined by bronchiolar epithelium and often filled with mucin and inflammatory cells 6.
Differential diagnosis
- air-space consolidation in the presence of pulmonary emphysema can mimic this appearance.
- in some situations, paraseptal emphysema and paracicatrical emphysema can also mimic honeycombing 3
Etymology
The term “honeycomb lung” is thought to have originated in the 19th century in Germany and is thought to have first appeared in 1949 in a study by N Oswald and T Parkinson 5.
See also
-<p><strong>Honeycombing</strong> refers to the computed tomographic (CT) manifestation of diffuse <a href="/articles/pulmonary-fibrosis" title="pulmonary fibrosis">pulmonary fibrosis</a> (usual interstitial pneumonia). CT demonstrates clustered cystic air spaces (between 0.3-1.0 cm in diameter), which are usually subpleural and basal in distribution. The walls of the cysts are well-defined and often thick (1-3 mm <sup>4</sup>). Honeycombing is an irreversible finding in <a href="/articles/interstitial-lung-disease" style="line-height: 1.5; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(224, 226, 225); margin-top: -1px; padding: 1px 0px;">interstitial lung disease</a> and associated with a poor prognosis.</p><h4>Differential diagnosis</h4><ul>-<li>air-space consolidation in the presence of pulmonary emphysema can mimic this appearance.</li>-<li>in some situations, <a href="/articles/paraseptal-emphysema" title="Paraseptal emphysema">paraseptal emphysema</a> and <a href="/articles/paracicatricial-emphysema" title="paracicatrical emphysematous change">paracicatrical emphysema</a> can also mimic honeycombing <sup>3</sup>-</li>- +<p><strong>Honeycombing</strong> refers to the computed tomographic (CT) manifestation of diffuse <a href="/articles/pulmonary-fibrosis">pulmonary fibrosis</a> (usual interstitial pneumonia). The Fleischner Society definition is clustered cystic air spaces (between 3-10mm in diameter but occasionally as large as 2.5 cm) which are usually subpleural and basal in distribution. The walls of the cysts are well-defined and often thick (1-3 mm) <sup><span style="font-size:10.8333px; line-height:11.5556px">4</span></sup><span style="line-height:1.6">. </span></p><p><span style="line-height:1.6">Honeycombing is an irreversible finding in </span><a style="line-height: 1.6;" href="/articles/interstitial-lung-disease">interstitial lung disease</a><span style="line-height:1.6"> and associated with a poor prognosis.</span></p><h4>Pathology</h4><p>Honeycombing consists of enlarged airspaces with thick fibrotic wall lined by bronchiolar epithelium and often filled with mucin and inflammatory cells <sup>6</sup>.</p><h4>Differential diagnosis</h4><ul>
- +<li>air-space consolidation in the presence of pulmonary emphysema can mimic this appearance.</li>
- +<li>in some situations, <a href="/articles/paraseptal-emphysema">paraseptal emphysema</a> and <a href="/articles/paracicatricial-emphysema">paracicatrical emphysema</a> can also mimic honeycombing <sup>3</sup>
- +</li>
-<li><a href="/articles/microcystic-honeycombing" title="Microcystic honeycombing">microcystic honeycombing</a></li>-<li><a href="/articles/macrocystic-honeycombing" title="macrocystic honeycombing">macrocystic honeycombing</a></li>- +<li><a href="/articles/microcystic-honeycombing">microcystic honeycombing</a></li>
- +<li><a href="/articles/macrocystic-honeycombing">macrocystic honeycombing</a></li>
References changed:
- 6. Wuyts W, Cavazza A, Rossi G, Bonella F, Sverzellati N, Spagnolo P. Differential Diagnosis of Usual Interstitial Pneumonia: When is It Truly Idiopathic? Eur Respir Rev. 2014;23(133):308-19. <a href="https://doi.org/10.1183/09059180.00004914">doi:10.1183/09059180.00004914</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/25176967">Pubmed</a>
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