Human epididymis protein 4
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Human epididymis protein 4 (HE4) is an emerging serum biomarker in the assessment of epithelial ovarian tumours. HE4 is a member of the whey associated protein (WAP) gene cluster, and has uncertain biological function 1.
Early results indicate that HE4 has higher sensitivity and sensitivity than CA-125 in distinguishing malignant from a benign ovarian disease in premenopausal women 2. HE4 has a high predictive value in ruling out invasive cancers in postmenopausal women with normal CA-125 2.
Elevated serum HE4 levels have been associated with a more aggressive epithelial ovarian carcinoma phenotype 3.
-<p><strong>Human epididymis protein 4 (HE4)</strong> is an emerging serum biomarker in the assessment of <a href="/articles/epithelial-ovarian-tumours">epithelial ovarian tumours</a>. HE4 is a member of the whey associated protein (WAP) gene cluster, and has uncertain biological function <sup>1</sup>.</p><p>Early results indicate that HE4 has higher sensitivity and sensitivity than <a href="/articles/ca-125">CA-125</a> in distinguishing malignant from benign ovarian disease in premenopausal women <sup>2</sup>. HE4 has a high predictive value in ruling out invasive cancers in postmenopausal women with normal CA-125 <sup>2</sup>.</p><p>Elevated serum HE4 levels have been associated with a more aggressive epithelial ovarian carcinoma phenotype <sup>3</sup>. </p>- +<p><strong>Human epididymis protein 4 (HE4)</strong> is an emerging serum biomarker in the assessment of <a href="/articles/epithelial-ovarian-tumours">epithelial ovarian tumours</a>. HE4 is a member of the whey associated protein (WAP) gene cluster and has uncertain biological function <sup>1</sup>.</p><p>Early results indicate that HE4 has higher sensitivity and sensitivity than <a href="/articles/ca-125">CA-125</a> in distinguishing malignant from a benign ovarian disease in premenopausal women <sup>2</sup>. HE4 has a high predictive value in ruling out invasive cancers in postmenopausal women with normal CA-125 <sup>2</sup>.</p><p>Elevated serum HE4 levels have been associated with a more aggressive epithelial ovarian carcinoma phenotype <sup>3</sup>. </p>
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