Human epididymis protein 4
Human epididymis protein 4 (HE4) is an emerging serum biomarker in the assessment of epithelial ovarian tumors. HE4 is a member of the whey associated protein (WAP) gene cluster, and has uncertain biological function 1.
Early results indicate that HE4 has higher sensitivity and sensitivity than CA-125 in distinguishing malignant from benign ovarian disease in premenopausal women 2. HE4 has a high predictive value in ruling out invasive cancers in postmenopausal women with normal CA-125 2.
Elevated serum HE4 levels have been associated with a more aggressive epithelial ovarian carcinoma phenotype 3.